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NLRC4 [cytosol]
Stable Identifier
R-HSA-561198
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IPAF, NLR family CARD domain-containing protein 4, NLRC4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
TP53 stimulates NLRC4 expression (Homo sapiens)
NLRC4 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The IPAF inflammasome (Homo sapiens)
IPAF is activated (Homo sapiens)
NLRC4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPP4 NLRC4
Gene Names
NLRC4, CARD12, CLAN, CLAN1, IPAF, UNQ6189/PRO20215
Chain
chain:1-1024
Reference Genes
BioGPS Gene:58484 NLRC4
COSMIC (genes):NLRC4 NLRC4
CTD Gene:58484 NLRC4
dbSNP Gene:58484 NLRC4
ENSEMBL:ENSG00000091106 NLRC4
ENSEMBL_homo_sapiens_GENE:ENSG00000091106.19 NLRC4
HGNC:16412 NLRC4
KEGG Gene (Homo sapiens):58484 NLRC4
Monarch:58484 NLRC4
NCBI Gene:58484 NLRC4
OMIM:606831 NLRC4
UCSC:Q9NPP4 NLRC4
Reference Transcript
RefSeq:NM_001302504.1 NLRC4
RefSeq:NM_001199138.1 NLRC4
RefSeq:NM_021209.4 NLRC4
RefSeq:NM_001199139.1 NLRC4
Other Identifiers
11735504_a_at
11735505_a_at
1552553_PM_a_at
1552553_a_at
1552554_PM_a_at
1552554_a_at
16896296
2547457
2547458
2547460
2547462
2547464
2547467
2547468
2547469
2547470
2547471
2547473
2547474
2547475
2547476
2547478
2547479
58484
8051396
A_23_P119835
GO:0000166
GO:0000287
GO:0002218
GO:0002221
GO:0002376
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0006919
GO:0006954
GO:0010954
GO:0012501
GO:0016045
GO:0023052
GO:0032731
GO:0042742
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043226
GO:0043231
GO:0045087
GO:0046456
GO:0050729
GO:0051092
GO:0051260
GO:0051604
GO:0061133
GO:0061702
GO:0065003
GO:0070269
GO:0072557
GO:0089720
GO:0097202
GO:0098542
GO:0098772
HMNXSV003035337
Hs2.23248.1.S1_3p_a_at
Hs2.23248.1.S2_3p_a_at
ILMN_1796976
PH_hs_0002045
TC02001723.hg
Participates
as an output of
TP53 stimulates NLRC4 expression (Homo sapiens)
as an input of
IPAF is activated (Homo sapiens)
as a component of
IPAF elicitors:NLRC4 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001186068.1
,
NP_001186067.1
,
NP_001289433.1
,
NP_067032.3
Guide to Pharmacology - Targets
1782
OpenTargets
ENSG00000091106
GeneCards
Q9NPP4
HPA
ENSG00000091106-NLRC4
Ensembl
ENST00000402280
,
ENSG00000091106
,
ENST00000360906
,
ENSP00000385428
,
ENSP00000339666
,
ENST00000342905
,
ENSP00000354159
PRO
Q9NPP4
Pharos - Targets
Q9NPP4
Orphanet
23504
PDB
8FVU
,
8FW2
,
8FW9
,
6N1I
,
6MKS
,
6K8J
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.743
4
UniProt:Q9NPP4 NLRC4
1
NLRC4 [cytosol]
(R-HSA-561198)
0.646
3
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.547
2
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