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PYCARD [cytosol]
Stable Identifier
R-HSA-561191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ASC, Apoptosis-associated speck-like protein containing a CARD, ASC_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
ASC binds Caspase-8 complex (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The AIM2 inflammasome (Homo sapiens)
dsDNA:AIM2 clusters bind ASC (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULZ3 PYCARD
Gene Names
PYCARD, ASC, CARD5, TMS1
Chain
chain:1-195
Reference Genes
BioGPS Gene:29108 PYCARD
COSMIC (genes):PYCARD PYCARD
CTD Gene:29108 PYCARD
dbSNP Gene:29108 PYCARD
ENSEMBL:ENSG00000103490 PYCARD
ENSEMBL_homo_sapiens_GENE:ENSG00000103490.14 PYCARD
HGNC:16608 PYCARD
KEGG Gene (Homo sapiens):29108 PYCARD
Monarch:29108 PYCARD
NCBI Gene:29108 PYCARD
OMIM:606838 PYCARD
UCSC:Q9ULZ3 PYCARD
Reference Transcript
RefSeq:NM_145182.2 PYCARD
RefSeq:NM_013258.4 PYCARD
Other Identifiers
11721169_a_at
11750531_a_at
16825997
221666_PM_s_at
221666_s_at
29108
3688312
3688313
3688314
3688315
3688317
3688318
3688319
3688320
46664_at
8001030
A_23_P26629
GE58507
GO:0000139
GO:0001773
GO:0002020
GO:0002218
GO:0002221
GO:0002230
GO:0002277
GO:0002376
GO:0002588
GO:0002821
GO:0005138
GO:0005515
GO:0005523
GO:0005576
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0006351
GO:0006355
GO:0006914
GO:0006915
GO:0006919
GO:0006954
GO:0007005
GO:0007010
GO:0007155
GO:0007165
GO:0007231
GO:0008092
GO:0008385
GO:0008656
GO:0009617
GO:0010506
GO:0010803
GO:0012501
GO:0016020
GO:0016192
GO:0017024
GO:0019899
GO:0023052
GO:0030838
GO:0031410
GO:0031647
GO:0032088
GO:0032090
GO:0032688
GO:0032722
GO:0032729
GO:0032731
GO:0032733
GO:0032755
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034774
GO:0035578
GO:0036211
GO:0042104
GO:0042771
GO:0042802
GO:0042803
GO:0042981
GO:0043025
GO:0043065
GO:0043124
GO:0043226
GO:0043280
GO:0044325
GO:0044351
GO:0044546
GO:0045087
GO:0046330
GO:0046456
GO:0046983
GO:0048870
GO:0050727
GO:0050729
GO:0050766
GO:0050829
GO:0050830
GO:0050870
GO:0051091
GO:0051092
GO:0051260
GO:0051607
GO:0060907
GO:0061702
GO:0065003
GO:0070269
GO:0070374
GO:0070700
GO:0071222
GO:0071347
GO:0071356
GO:0071901
GO:0072332
GO:0072558
GO:0072559
GO:0090200
GO:0097169
GO:0098542
GO:0098772
GO:0140738
GO:1900016
GO:1901224
GO:2000406
GO:2001056
GO:2001238
GO:2001242
HMNXSV003043000
ILMN_1698766
ILMN_2398274
PH_hs_0022963
TC16001052.hg
g13325315_3p_a_at
Participates
as a component of
NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] (Homo sapiens)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
Pyrin trimer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
as an input of
ASC binds Caspase-8 complex (Homo sapiens)
dsDNA:AIM2 clusters bind ASC (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
Other forms of this molecule
PYCARD [azurophil granule lumen]
PYCARD [extracellular region]
PYCARD [secretory granule lumen]
Inferred To
Pycard [cytosol]
(Mus musculus)
Pycard [cytosol]
(Rattus norvegicus)
PYCARD [cytosol]
(Bos taurus)
PYCARD [cytosol]
(Canis familiaris)
PYCARD [cytosol]
(Sus scrofa)
pycard [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_660183.1
,
NP_037390.2
OpenTargets
ENSG00000103490
HPA
ENSG00000103490-PYCARD
GeneCards
Q9ULZ3
Ensembl
ENSG00000103490
,
ENSP00000340441
,
ENST00000350605
,
ENST00000247470
,
ENSP00000247470
PRO
Q9ULZ3
Pharos - Targets
Q9ULZ3
HMDB Protein
HMDBP13951
PDB
6KI0
,
5H8O
,
1UCP
,
6K99
,
3J63
,
6N1H
,
2KN6
,
7KEU
,
7E5B
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96P20 NLRP3
2
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
NLRP3 [cytosol]
(R-HSA-561189)
0.948
26
UniProt:O14862 AIM2
1
AIM2 [cytosol]
(R-HSA-874111)
0.892
13
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.861
11
UniProt:O15553 MEFV
1
MEFV [cytosol]
(R-HSA-877355)
0.796
10
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.789
8
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.619
7
UniProt:Q56P42 PYDC2
0.602
4
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.591
4
UniProt:Q9C000 NLRP1
1
NLRP1 [cytosol]
(R-HSA-561196)
0.558
5
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.556
5
UniProt:Q7RTR2 NLRC3
1
NLRC3 [cytosol]
(R-HSA-561197)
0.556
3
UniProt:Q9NPP4 NLRC4
1
NLRC4 [cytosol]
(R-HSA-561198)
0.547
2
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.512
4
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.512
5
UniProt:Q8WXC3 PYDC1
0.463
2
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