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NLRP3 [cytosol]
Stable Identifier
R-HSA-561189
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NACHT, LRR and PYD domains-containing protein 3, NALP3_HUMAN, Cryopyrin
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 8b binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 N binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96P20 NLRP3
Gene Names
NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
Chain
chain:1-1036
Reference Genes
BioGPS Gene:114548 NLRP3
COSMIC (genes):NLRP3 NLRP3
CTD Gene:114548 NLRP3
dbSNP Gene:114548 NLRP3
ENSEMBL:ENSG00000162711 NLRP3
HGNC:16400 NLRP3
KEGG Gene (Homo sapiens):114548 NLRP3
Monarch:114548 NLRP3
NCBI Gene:114548 NLRP3
OMIM:606416 NLRP3
UCSC:Q96P20 NLRP3
Reference Transcript
RefSeq:NM_001079821.2 NLRP3
RefSeq:NM_001127462.2 NLRP3
RefSeq:NM_183395.2 NLRP3
RefSeq:XM_017000184.1 NLRP3
RefSeq:NM_001243133.1 NLRP3
RefSeq:XM_017000182.1 NLRP3
RefSeq:NM_001127461.2 NLRP3
RefSeq:XM_011544048.2 NLRP3
RefSeq:XM_017000183.1 NLRP3
RefSeq:NM_004895.4 NLRP3
RefSeq:XM_017000181.1 NLRP3
Participates
as a component of
BRISC complex:NLRP3 [cytosol] (Homo sapiens)
NLRP3:MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
8b:NLRP3 [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
N:NLRP3 [cytosol] (Homo sapiens)
as a repeated unit of
NLRP3 oligomer [cytosol] (Homo sapiens)
as an input of
SARS-CoV-1 8b binds NLRP3 (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)
SARS-CoV-2 N binds NLRP3 (Homo sapiens)
as an output of
Expression of NLRP3 gene (Homo sapiens)
Other forms of this molecule
K63polyUb-NLRP3 [cytosol]
Inferred To
LOC108644478 [cytosol]
(Xenopus tropicalis)
Homologues of NLRP3 [cytosol]
(Xenopus tropicalis)
NLRP3 [cytosol]
(Bos taurus)
NLRP3 [cytosol]
(Canis familiaris)
NLRP3 [cytosol]
(Danio rerio)
NLRP3 [cytosol]
(Gallus gallus)
NLRP3 [cytosol]
(Mus musculus)
NLRP3 [cytosol]
(Rattus norvegicus)
NLRP3 [cytosol]
(Sus scrofa)
LOC100491706 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016855670.1
,
NP_001230062.1
,
NP_899632.1
,
XP_011542350.1
,
NP_001073289.1
,
NP_001120933.1
,
XP_016855673.1
,
XP_016855671.1
,
NP_001120934.1
,
XP_016855672.1
,
NP_004886.3
Guide to Pharmacology - Targets
1770
OpenTargets
ENSG00000162711
GeneCards
Q96P20
PRO
Q96P20
Pharos - Targets
Q96P20
Orphanet
16553
PDB
8ERT
,
8EJ4
,
7ALV
,
2NAQ
,
6NPY
,
8SWF
,
3QF2
,
8WSM
,
8SWK
,
7ZGU
,
7PZC
,
7VTP
,
8RI2
,
8ETR
,
7PZD
,
8SXN
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.948
26
UniProt:Q8TDX7 NEK7
2
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
NEK7 [cytosol]
(R-HSA-2530599)
0.675
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.628
18
UniProt:P19525 EIF2AK2
5
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
EIF2AK2 [cytosol]
(R-HSA-168699)
0.602
6
UniProt:Q96P20 NLRP3
2
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
NLRP3 [cytosol]
(R-HSA-561189)
0.573
2
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
4
UniProt:Q9ES74 NEK7
0.524
2
UniProt:Q80H93 8b
1
8b [cytosol]
(R-COV-9678168)
0.463
7
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