Reactome | RGL1 [cytosol]

RGL1 [cytosol]

Stable Identifier

R-HSA-561160

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ral guanine nucleotide dissociation stimulator-like 1, RGL1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS:GTP binds RAL GDS proteins (Homo sapiens)
        
        RAL GDS proteins [cytosol] (Homo sapiens)
        
        RGL1 [cytosol] (Homo sapiens)
        
        S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins [plasma membrane] (Homo sapiens)
        
        RAL GDS proteins [cytosol] (Homo sapiens)
        
        RGL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZL6 RGL1

Gene Names

RGL1, KIAA0959, RGL

Chain

chain:1-768

Reference Genes

BioGPS Gene:23179 RGL1

COSMIC (genes):RGL1 RGL1

CTD Gene:23179 RGL1

dbSNP Gene:23179 RGL1

ENSEMBL:ENSG00000143344 RGL1

ENSEMBL:ENSG00000143344.16 RGL1

HGNC:30281 RGL1

KEGG Gene (Homo sapiens):23179 RGL1

Monarch:23179 RGL1

NCBI Gene:23179 RGL1

OMIM:605667 RGL1

UCSC:Q9NZL6 RGL1

Reference Transcript

Other Identifiers

11743189_a_at

11747969_a_at

11751036_a_at

11757824_s_at

16674927

209568_PM_s_at

209568_s_at

23179

2371347

2371366

2371367

2371384

2371385

2371386

2371397

2371401

2371407

2371411

2371412

2371413

2371416

2371417

2371419

2371423

2371424

2371425

2371426

2371428

2371430

2371432

2371433

2371435

2371436

2371438

2371439

2371441

37539_at

74957_at

7908125

A_14_P112725

A_14_P129733

A_23_P115417

A_33_P3240532

GE53625

GO:0005085

GO:0005515

GO:0005575

GO:0005829

GO:0005886

GO:0007165

GO:0007264

GO:0007265

GO:0023052

GO:0043547

GO:0098772

HMNXSV003030912

ILMN_1654398

TC01001587.hg

g7682470_3p_a_at

Participates

as an output of

Expression of RGL1 (Homo sapiens)

as a member of

RAL GDS proteins [cytosol] (Homo sapiens)

Inferred To

rgl-1 [cytosol] (Caenorhabditis elegans)

RGL1 [cytosol] (Bos taurus)

RGL1 [cytosol] (Canis familiaris)

RGL1 [cytosol] (Gallus gallus)

RGL1 [cytosol] (Sus scrofa)

gefD [cytosol] (Dictyostelium discoideum)

Rgl1 [cytosol] (Mus musculus)

Rgl1 [cytosol] (Rattus norvegicus)

gefM [cytosol] (Dictyostelium discoideum)

LTE1 [cytosol] (Saccharomyces cerevisiae)

gefC [cytosol] (Dictyostelium discoideum)

Homologues of RGL1 [cytosol] (Dictyostelium discoideum)

Rgl [cytosol] (Drosophila melanogaster)

ste6 [cytosol] (Schizosaccharomyces pombe)

rgl1 [cytosol] (Danio rerio)

gefN [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_055964.3, NP_001284599.1, NP_001284598.1, NP_001284601.1, XP_011507641.1, NP_001284600.1

OpenTargets

ENSG00000143344

GeneCards

Q9NZL6

HPA

ENSG00000143344-RGL1

Ensembl

ENST00000360851, ENSG00000143344, ENST00000304685, ENSP00000354097, ENSP00000303192

PRO

Q9NZL6

Pharos - Targets

Q9NZL6

HMDB Protein

HMDBP11477

PDB

7SCX, 7SCW

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.667	3

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