21695114 |
Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened
Yue, T,
Jia, J,
Ma, G,
Sasai, N,
Briscoe, J,
Jiang, J,
Chen, Y
|
PLoS Biol. |
2011 |
20207148 |
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
Ayers, KL,
Thérond, PP
|
Trends Cell Biol. |
2010 |
20412786 |
Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations
Mas, C,
Ruiz i Altaba, A
|
Biochem. Pharmacol. |
2010 |
10966113 |
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
Cohen, SM,
Denef, N,
Neubüser, D,
Perez, L
|
Cell |
2000 |
23719536 |
The mechanisms of Hedgehog signalling and its roles in development and disease
Thérond, PP,
Briscoe, J
|
Nat. Rev. Mol. Cell Biol. |
2013 |
19365551 |
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
Chuang, PT,
Wilson, CW,
Chen, MH
|
PLoS ONE |
2009 |
20844016 |
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
Zhao, Y,
Jia, J,
Li, S,
Tong, C,
Liu, Y,
Wang, B,
Jiang, J,
Chen, Y
|
Genes Dev. |
2010 |
17200122 |
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
Beachy, PA,
Carlson, M,
Sever, N,
Dwyer, JR,
Parhami, F,
Nelson, SF
|
J. Biol. Chem. |
2007 |
24925320 |
Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception
Zhang, YE,
Shen, QH,
Tang, LY,
Chen, Y,
Yue, S,
Zhang, Z,
Tang, Y,
Tang, Y,
Ding, J,
Cheng, SY,
Yu, TT
|
Elife |
2014 |
24302888 |
Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover
Wang, H,
Liu, F,
Sun, L,
Chen, Z,
Lv, X,
Zhu, Y,
Huang, S,
Sun, Q,
Lu, Y,
Tao, Y,
Zhang, C,
Zhao, Y,
Zhang, J,
Zhang, Z,
Yang, S,
Zheng, X,
Chen, D
|
PLoS Biol. |
2013 |
22231273 |
Oxysterols are allosteric activators of the oncoprotein Smoothened
Schlesinger, PH,
Rammohan, J,
Nachtergaele, S,
Rohatgi, R,
Covey, DF,
Mydock, LK,
Krishnan, K
|
Nat. Chem. Biol. |
2012 |
12192414 |
Patched acts catalytically to suppress the activity of Smoothened
Cooper, MK,
Maiti, T,
Beachy, PA,
Taipale, J
|
Nature |
2002 |
21801010 |
Gli proteins in development and disease
Hui, CC,
Angers, S
|
Annu. Rev. Cell Dev. Biol. |
2011 |
19996169 |
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
Kim, J,
Kato, M,
Beachy, PA
|
Proc. Natl. Acad. Sci. U.S.A. |
2009 |
16707575 |
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
Scott, MP,
Corcoran, RB
|
Proc. Natl. Acad. Sci. U.S.A. |
2006 |
16136078 |
Vertebrate Smoothened functions at the primary cilium
Stainier, DY,
Singla, V,
Norman, AR,
Reiter, JF,
Aanstad, P,
Corbit, KC
|
Nature |
2005 |
19196978 |
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
Walsh, CT,
McMahon, AP,
Wang, Y,
Zhou, Z
|
Proc. Natl. Acad. Sci. U.S.A. |
2009 |
19948480 |
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
Milenkovic, L,
Rohatgi, R,
Scott, MP
|
J. Cell Biol. |
2009 |
22007132 |
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
Tuson, M,
He, M,
Anderson, KV
|
Development |
2011 |
19906846 |
Patched regulates Smoothened trafficking using lipoprotein-derived lipids
Eugster, C,
Khaliullina, H,
Carvalho, M,
Riedel, F,
Eaton, S,
Panáková, D
|
Development |
2009 |
16339192 |
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
Huangfu, D,
Anderson, KV
|
Development |
2006 |
20395968 |
The primary cilium: a signalling centre during vertebrate development
Anderson, KV,
Goetz, SC
|
Nat. Rev. Genet. |
2010 |
17762891 |
Patching the gaps in Hedgehog signalling
Rohatgi, R,
Scott, MP
|
Nat. Cell Biol. |
2007 |
17960137 |
Hedgehog regulates smoothened activity by inducing a conformational switch
Tong, C,
Jiang, J,
Zhao, Y
|
Nature |
2007 |
17641202 |
Patched1 regulates hedgehog signaling at the primary cilium
Milenkovic, L,
Rohatgi, R,
Scott, MP
|
Science |
2007 |