GLI2 is degraded by the proteasome

Stable Identifier
R-HSA-5610757
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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After being ubiquitinated, the bulk of GLI2 is fully degraded by the proteasome; a small fraction of GLI2 may be converted to the repressor form after ubiquitination (Pan et al, 2006; Pan and Wang, 2007).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Inferred From
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Reviewed
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