SCF(beta-TrCP) ubiquitinates p-GLI3

Stable Identifier
R-HSA-5610746
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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SCF(beta-TrCP) ubiquitinates p-GLI3
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Hyperphosphorylated GLI3 binds directly with beta-TrCP though at least three independent domains and is polyubiquitinated at lysines 773, 778, 784 and 800 (Tempe et al, 2006). After ubiquitination, GLI3 is processed to the truncated repressor form by the proteasome (Tempe et al, 2006; Wang and Li, 2006)

Literature References
PubMed ID Title Journal Year
16371461 Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

Wang, B, Li, Y

Proc. Natl. Acad. Sci. U.S.A. 2006
16705181 Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP

Tempe, D, Casas, M, Karaz, S, Blanchet-Tournier, MF, Concordet, JP

Mol Cell Biol 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
Physical Entity
BTRC:CUL1:RBX1:SKP1 [cytosol]
Activity
ubiquitin-protein transferase activity (0004842)
Orthologous Events
SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)