SCF(beta-TrCP) ubiquitinates p-GLI3

Stable Identifier
R-HSA-5610746
Type
Reaction
Species
Homo sapiens
Compartment
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Hyperphosphorylated GLI3 binds directly with beta-TrCP though at least three independent domains and is polyubiquitinated at lysines 773, 778, 784 and 800 (Tempe et al, 2006). After ubiquitination, GLI3 is processed to the truncated repressor form by the proteasome (Tempe et al, 2006; Wang and Li, 2006)

Literature References
PubMed ID Title Journal Year
16705181 Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP

Tempe, D, Concordet, JP, Casas, M, Blanchet-Tournier, MF, Karaz, S

Mol Cell Biol 2006
16371461 Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

Wang, B, Li, Y

Proc. Natl. Acad. Sci. U.S.A. 2006
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]

Orthologous Events
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