Hyperphosphorylated GLI3 binds directly with beta-TrCP though at least three independent domains and is polyubiquitinated at lysines 773, 778, 784 and 800 (Tempe et al, 2006). After ubiquitination, GLI3 is processed to the truncated repressor form by the proteasome (Tempe et al, 2006; Wang and Li, 2006)
Tempe, D, Concordet, JP, Casas, M, Blanchet-Tournier, MF, Karaz, S
Wang, B, Li, Y
ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
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