CK1 phosphorylates p-GLI3

Stable Identifier
R-HSA-5610722
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CK1 phosphorylates p-GLI3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation by PKA primes GLI3 for subsequent phosphorylation by CK1 at four or more sites. These serial phosphorylations are required for the recruitment of beta-TrCP and subsequent ubiquitination and processing of GLI3 (Tempe et al, 2006; Wang and Li, 2006; Wen et al, 2010; Schrader et al, 2011)

Literature References
PubMed ID Title Journal Year
20154143 Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ

Mol. Cell. Biol. 2010
16705181 Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP

Tempe, D, Casas, M, Karaz, S, Blanchet-Tournier, MF, Concordet, JP

Mol Cell Biol 2006
21921029 A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

Schrader, EK, Harstad, KG, Holmgren, RA, Matouschek, A

J. Biol. Chem. 2011
16371461 Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

Wang, B, Li, Y

Proc. Natl. Acad. Sci. U.S.A. 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CSNK1A1 [cytosol]
Physical Entity
CSNK1A1 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
CK1 phosphorylates p-GLI3 (Bos taurus)
CK1 phosphorylates p-GLI3 (Canis familiaris)
CK1 phosphorylates p-GLI3 (Danio rerio)
CK1 phosphorylates p-GLI3 (Drosophila melanogaster)
CK1 phosphorylates p-GLI3 (Mus musculus)
CK1 phosphorylates p-GLI3 (Rattus norvegicus)
CK1 phosphorylates p-GLI3 (Sus scrofa)
CK1 phosphorylates p-GLI3 (Xenopus tropicalis)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)