Reactome | CK1 phosphorylates p-GLI3

CK1 phosphorylates p-GLI3

Stable Identifier

R-HSA-5610722

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation by PKA primes GLI3 for subsequent phosphorylation by CK1 at four or more sites. These serial phosphorylations are required for the recruitment of beta-TrCP and subsequent ubiquitination and processing of GLI3 (Tempe et al, 2006; Wang and Li, 2006; Wen et al, 2010; Schrader et al, 2011)

Literature References

PubMed ID	Title	Journal	Year
16705181	Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP Tempe, D, Casas, M, Karaz, S, Blanchet-Tournier, MF, Concordet, JP	Mol Cell Biol	2006
20154143	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ	Mol. Cell. Biol.	2010
21921029	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome Schrader, EK, Harstad, KG, Holmgren, RA, Matouschek, A	J. Biol. Chem.	2011
16371461	Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing Wang, B, Li, Y	Proc. Natl. Acad. Sci. U.S.A.	2006