Phosphorylation by PKA primes GLI3 for subsequent phosphorylation by CK1 at four or more sites. These serial phosphorylations are required for the recruitment of beta-TrCP and subsequent ubiquitination and processing of GLI3 (Tempe et al, 2006; Wang and Li, 2006; Wen et al, 2010; Schrader et al, 2011)
Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ
Tempe, D, Casas, M, Karaz, S, Blanchet-Tournier, MF, Concordet, JP
Schrader, EK, Harstad, KG, Holmgren, RA, Matouschek, A
Wang, B, Li, Y
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