Reactome | PKA phosphorylates GLI3

PKA phosphorylates GLI3

Stable Identifier

R-HSA-5610720

Type

Reaction [transition]

Species

Homo sapiens

Compartment

ciliary base

ReviewStatus

5/5

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Phosphorylation of GLI3 by PKA on up to six sites in the C-terminal region primes the protein for subsequent phosphorylation by CK1 and GSK3 and is required for the ubiquitin-mediated processing by the proteasome to yield the truncated repressor form (Tempe et al, 2006; Pan et al, 2006; Pan and Wang, 2007; Wang and Li, 2006). Processing of GLI3 is regulated in part by movement through the primary cilia, and disruption of intraflagellar transport abrogates processing (Wen et al, 2010)

Literature References

PubMed ID	Title	Journal	Year
16705181	Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP Tempe, D, Casas, M, Karaz, S, Blanchet-Tournier, MF, Concordet, JP	Mol Cell Biol	2006
17283082	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome Pan, Y, Wang, B	J. Biol. Chem.	2007
20154143	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ	Mol. Cell. Biol.	2010
16611981	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Pan, Y, Bai, CB, Joyner, AL, Wang, B	Mol. Cell. Biol.	2006
16371461	Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing Wang, B, Li, Y	Proc. Natl. Acad. Sci. U.S.A.	2006