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SLC22A8 [plasma membrane]
Stable Identifier
R-HSA-561061
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OAT3, Solute carrier family 22 member 8, S22A8_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic anion transport (Homo sapiens)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)
OAT1-3 [plasma membrane] (Homo sapiens)
SLC22A8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TCC7 SLC22A8
Gene Names
SLC22A8, OAT3
Chain
chain:1-542
Reference Genes
BioGPS Gene:9376 SLC22A8
COSMIC (genes):SLC22A8 SLC22A8
CTD Gene:9376 SLC22A8
dbSNP Gene:9376 SLC22A8
ENSEMBL:ENSG00000149452 SLC22A8
ENSEMBL_homo_sapiens_GENE:ENSG00000149452.16 SLC22A8
HGNC:10972 SLC22A8
KEGG Gene (Homo sapiens):9376 SLC22A8
Monarch:9376 SLC22A8
NCBI Gene:9376 SLC22A8
OMIM:607581 SLC22A8
UCSC:Q8TCC7 SLC22A8
Reference Transcript
RefSeq:NM_001184732.1 SLC22A8
RefSeq:NM_001184733.1 SLC22A8
RefSeq:NM_004254.3 SLC22A8
RefSeq:NM_001184736.1 SLC22A8
RefSeq:XM_011545364.1 SLC22A8
Other Identifiers
11725993_a_at
11747810_a_at
11755865_x_at
16739673
221298_PM_s_at
221298_s_at
231352_PM_at
231352_at
3376368
3376369
3376370
3376371
3376373
3376375
3376377
3376380
3376381
3376382
3376384
3376385
3376390
3376391
3376392
45884_at
7948937
9376
A_24_P304311
GO:0003013
GO:0005215
GO:0005452
GO:0005576
GO:0005615
GO:0005886
GO:0006811
GO:0006869
GO:0008514
GO:0009636
GO:0009925
GO:0015132
GO:0015297
GO:0015698
GO:0015732
GO:0016020
GO:0016323
GO:0016324
GO:0022857
GO:0042908
GO:0042910
GO:0043226
GO:0055085
GO:0070062
GO:0150104
Hs.330195.0.A1_3p_at
ILMN_1783756
PH_hs_0013670
TC11001887.hg
Participates
as a member of
OAT1-3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SLC22A8 [basolateral plasma membrane]
Inferred To
Orct [plasma membrane]
(Drosophila melanogaster)
Dmel\CG16727 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14855 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4630 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7342 [plasma membrane]
(Drosophila melanogaster)
pes-23 [plasma membrane]
(Caenorhabditis elegans)
slc22a8 [plasma membrane]
(Xenopus tropicalis)
Dmel\CG10486 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6356 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG5592 [plasma membrane]
(Drosophila melanogaster)
CG6596 [plasma membrane]
(Drosophila melanogaster)
CT19169 [plasma membrane]
(Drosophila melanogaster)
CarT [plasma membrane]
(Drosophila melanogaster)
oct-2 [plasma membrane]
(Caenorhabditis elegans)
suex-2 [plasma membrane]
(Caenorhabditis elegans)
CG31530-RA [plasma membrane]
(Drosophila melanogaster)
CG8654-RA [plasma membrane]
(Drosophila melanogaster)
Homologues of SLC22A8 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SLC22A8 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17752 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7333 [plasma membrane]
(Drosophila melanogaster)
Orct2 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4465 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14857 [plasma membrane]
(Drosophila melanogaster)
SLC22A8 [plasma membrane]
(Bos taurus)
SLC22A8 [plasma membrane]
(Caenorhabditis elegans)
SLC22A8 [plasma membrane]
(Canis familiaris)
SLC22A8 [plasma membrane]
(Sus scrofa)
Slc22a8 [plasma membrane]
(Mus musculus)
Slc22a8 [plasma membrane]
(Rattus norvegicus)
Dmel\CG4462 [plasma membrane]
(Drosophila melanogaster)
oct-1 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG7084 [plasma membrane]
(Drosophila melanogaster)
Balat [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14856 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6231 [plasma membrane]
(Drosophila melanogaster)
SLC22A [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17751 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7458 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4459 [plasma membrane]
(Drosophila melanogaster)
slc22a6 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001171661.1
,
NP_004245.2
,
NP_001171665.1
,
NP_001171662.1
,
XP_011543666.1
ZINC - World Drugs
S22A8_HUMAN
Guide to Pharmacology - Targets
1027
OpenTargets
ENSG00000149452
ZINC - FDA approved
S22A8_HUMAN
ZINC - Substances
S22A8_HUMAN
ZINC target
Q8TCC7
ZINC - Biogenic
S22A8_HUMAN
PRO
Q8TCC7
ZINC - Investigational
S22A8_HUMAN
ZINC - Metabolites
S22A8_HUMAN
HPA
ENSG00000149452-SLC22A8
GeneCards
Q8TCC7
Ensembl
ENSP00000398548
,
ENSP00000443368
,
ENST00000545207
,
ENST00000336232
,
ENSP00000337335
,
ENST00000535878
,
ENSG00000149452
,
ENSP00000441658
,
ENST00000430500
Pharos - Targets
Q8TCC7
Orphanet
27933
ZINC - Predictions - Purchasable
S22A8_HUMAN
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