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SMO dimer [endocytic vesicle membrane]
Stable Identifier
R-HSA-5610574
Type
Complex
Species
Homo sapiens
Compartment
endocytic vesicle membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)
SMO dimer [endocytic vesicle membrane] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
Activation of SMO (Homo sapiens)
SMO dimer binds ARRB and KIF3A (Homo sapiens)
SMO dimer [endocytic vesicle membrane] (Homo sapiens)
SMO dimer:ARRB:KIF3A [endocytic vesicle membrane] (Homo sapiens)
SMO dimer [endocytic vesicle membrane] (Homo sapiens)
SMO translocates to the cilium (Homo sapiens)
SMO dimer [endocytic vesicle membrane] (Homo sapiens)
SMO dimer:ARRB:KIF3A [endocytic vesicle membrane] (Homo sapiens)
SMO dimer [endocytic vesicle membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17960137
Hedgehog regulates smoothened activity by inducing a conformational switch
Tong, C
,
Jiang, J
,
Zhao, Y
Nature
2007
Participants
components
x 2
SMO [endocytic vesicle membrane]
(Homo sapiens)
Participates
as an input of
SMO dimer binds ARRB and KIF3A (Homo sapiens)
SMO translocates to the cilium (Homo sapiens)
PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)
as a component of
SMO dimer:ARRB:KIF3A [endocytic vesicle membrane] (Homo sapiens)
Inferred To
SMO dimer [endocytic vesicle membrane]
(Bos taurus)
SMO dimer [endocytic vesicle membrane]
(Canis familiaris)
SMO dimer [endocytic vesicle membrane]
(Drosophila melanogaster)
SMO dimer [endocytic vesicle membrane]
(Gallus gallus)
SMO dimer [endocytic vesicle membrane]
(Mus musculus)
SMO dimer [endocytic vesicle membrane]
(Rattus norvegicus)
SMO dimer [endocytic vesicle membrane]
(Sus scrofa)
SMO dimer [endocytic vesicle membrane]
(Xenopus tropicalis)
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