Reactome | KIF7 [ciliary tip]

KIF7 [ciliary tip]

Stable Identifier

R-HSA-5610395

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary tip

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Locations in the PathwayBrowser for interactor UniProt:P07197 NFM

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External Reference Information

External Reference

UniProt:Q2M1P5 KIF7

Gene Names

KIF7, UNQ340/PRO539

Chain

chain:1-1343

Reference Genes

BioGPS Gene:374654 KIF7

COSMIC (genes):KIF7 KIF7

CTD Gene:374654 KIF7

dbSNP Gene:374654 KIF7

ENSEMBL:ENSG00000166813 KIF7

HGNC:30497 KIF7

KEGG:hsa:374654 KIF7

Monarch:374654 KIF7

NCBI Gene:374654 KIF7

OMIM:611254 KIF7

UCSC:Q2M1P5 KIF7

Reference Transcript

RefSeq:NM_198525.2 KIF7

Other Identifiers

11728419_at

16813148

229405_PM_at

229405_at

3638485

3638486

3638490

3638491

3638492

3638493

3638494

3638495

3638496

3638499

3638500

3638502

3638505

3638507

3638508

3638509

3638511

3638513

3638514

3638515

3638516

3638517

3638518

3638520

3638522

3638524

3638526

3638528

3638531

3638532

3638533

3638534

3638535

3638537

3638538

3638541

3638545

374654

73617_at

7991296

80317_at

A_24_P203689

GE556590

GO:0003774

GO:0003777

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005815

GO:0005856

GO:0005871

GO:0005874

GO:0005929

GO:0007018

GO:0008017

GO:0008092

GO:0016787

GO:0016887

GO:0036064

GO:0043226

GO:0045879

GO:0045880

GO:0097542

GO:0140657

HMNXSV003012103

HMNXSV003025150

Hs.119824.0.A1_3p_at

ILMN_1654916

PH_hs_0025843

PH_hs_0039067

TC15001832.hg

TC15001833.hg

Participates

as a component of

KIF7:microtubule [ciliary tip] (Homo sapiens)

as an input of

KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)

This entity regulates

Positively

GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)

Inferred To

KIF7 [ciliary tip] (Bos taurus)

KIF7 [ciliary tip] (Canis familiaris)

KIF7 [ciliary tip] (Danio rerio)

KIF7 [ciliary tip] (Dictyostelium discoideum)

KIF7 [ciliary tip] (Drosophila melanogaster)

KIF7 [ciliary tip] (Gallus gallus)

KIF7 [ciliary tip] (Mus musculus)

KIF7 [ciliary tip] (Rattus norvegicus)

KIF7 [ciliary tip] (Sus scrofa)

Cross References

RefSeq

NP_940927.2

ENSEMBL

ENST00000394412, ENSP00000377934

OpenTargets

ENSG00000166813

HPA

ENSG00000166813-KIF7

PRO

Q2M1P5

Pharos - Targets

Q2M1P5

Orphanet

KIF7

PDB

4A14, 7RX0, 6MLQ, 6MLR, 2XT3

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.569	3
UniProt:P10070 GLI2	11	GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) p11S-GLI2 [ciliary base] (R-HSA-5610471) p8S-GLI2 [ciliary base] (R-HSA-5610494) p4S-GLI2 [ciliary base] (R-HSA-5610487) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059)	0.569	3
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.564	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:P07197 NFM			0.527	2
UniProt:O75558 STX11			0.527	2
UniProt:Q9UPT9 USP22	1	USP22 [nucleoplasm] (R-HSA-3662288)	0.527	2
UniProt:Q9BW66 CINP			0.527	2
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.527	3
UniProt:Q9BRK4 LZTS2			0.527	2
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.527	3
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.527	3
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.527	2
UniProt:Q14314 FGL2	2	FGL2 [extracellular region] (R-HSA-6801586) FGL2 [ficolin-1-rich granule lumen] (R-HSA-6801499)	0.527	2
UniProt:Q8TF09 DYNLRB2	2	DYNLRB2 [ciliary tip] (R-HSA-5625341) DYNLRB2 [cilium] (R-HSA-5624869)	0.508	2
UniProt:Q9Y2D8 ADIP			0.483	2
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.483	4

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