p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane

Stable Identifier
R-HSA-5607755
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Tyrosine-phosphorylated Phospholipase C-gamma 2 (PLCG2) translocates from the cytosol to the plasma membrane. At the membrane PLCG2 is in close proximity to phosphatidylinositol 4,5-bisphosphate (PIP2) and its other substrates generating the second messengers IP3 and DAG (Rhee 2001). This leads to the activation of CARD9-BCL10-MALT1/NF-kB signaling and stimulates calcineurin/NFAT signaling.

Literature References
PubMed ID Title Journal Year
8972730 Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate

Kawakami, N, Shimohama, S, Hayakawa, T, Sumida, Y, Fujimoto, S

Biochim. Biophys. Acta 1996
11606584 Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling

Rodriguez, R, Matsuda, M, Perisic, O, Bravo, J, Paul, A, Jones, NP, Light, Y, Swann, K, Williams, RL, Katan, M

J Biol Chem 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created