p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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Tyrosine-phosphorylated Phospholipase C-gamma 2 (PLCG2) translocates from the cytosol to the plasma membrane. At the membrane PLCG2 is in close proximity to phosphatidylinositol 4,5-bisphosphate (PIP2) and its other substrates generating the second messengers IP3 and DAG (Rhee 2001). This leads to the activation of CARD9-BCL10-MALT1/NF-kB signaling and stimulates calcineurin/NFAT signaling.

Literature References
PubMed ID Title Journal Year
8972730 Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate

Kawakami, N, Shimohama, S, Hayakawa, T, Sumida, Y, Fujimoto, S

Biochim. Biophys. Acta 1996
11606584 Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling

Rodriguez, R, Matsuda, M, Perisic, O, Bravo, J, Paul, A, Jones, NP, Light, Y, Swann, K, Williams, RL, Katan, M

J Biol Chem 2001
Participant Of
Orthologous Events
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