The signalling abilities of CLEC7A (Dectin-1) depend on its cytoplasmic (immunoreceptor tyrosine based activation motif) ITAM-like motif. In contrast to traditional ITAM sequences which consists of dual YXXL sequences, CLEC7A's ITAM (hemi-ITAM) has only a single YXXL motif (Ariizumi et al. 2000). Despite its unusual ITAM, CLEC7A upon ligation with beta-glucan containing particles undergoes tyrosine phoshorylation by SRC kinases (Kerrigan & Brown 2010).
Gordon, S, Rogers, NC, Slack, EC, Williams, DL, Edwards, AD, Brown, GD, Schweighoffer, E, Reis e Sousa, C, Nolte, MA, Tybulewicz, VL, Schulz, O
Brown, GD
Magee, AS, Wolf, AJ, Weiss, A, Vasilakos, JP, Katsumoto, TR, Goodridge, HS, Danielson, ME, Chan, AS, Bose, N, Underhill, DM, Ma, J, Reyes, CN, Becker, CA
Edelbaum, D, Bergstresser, PR, Morita, A, Shikano, S, Ariizumi, K, Kumamoto, T, Shen, GL, Ritter, R, Xu, S, Takashima, A
Kerrigan, AM, Brown, GD
protein tyrosine kinase activity of SRC-1 [plasma membrane]
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