SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan

Stable Identifier
Reaction [transition]
Homo sapiens
SRC kinase phosphorylates Dectin-1:1,3-beta-D-glucan
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The signalling abilities of CLEC7A (Dectin-1) depend on its cytoplasmic (immunoreceptor tyrosine based activation motif) ITAM-like motif. In contrast to traditional ITAM sequences which consists of dual YXXL sequences, CLEC7A's ITAM (hemi-ITAM) has only a single YXXL motif (Ariizumi et al. 2000). Despite its unusual ITAM, CLEC7A upon ligation with beta-glucan containing particles undergoes tyrosine phoshorylation by SRC kinases (Kerrigan & Brown 2010).

Literature References
PubMed ID Title Journal Year
15845454 Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

Gordon, S, Rogers, NC, Slack, EC, Williams, DL, Edwards, AD, Brown, GD, Schweighoffer, E, Reis e Sousa, C, Nolte, MA, Tybulewicz, VL, Schulz, O

Immunity 2005
16341139 Dectin-1: a signalling non-TLR pattern-recognition receptor

Brown, GD

Nat. Rev. Immunol. 2006
21525931 Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'

Magee, AS, Wolf, AJ, Weiss, A, Vasilakos, JP, Katsumoto, TR, Goodridge, HS, Danielson, ME, Chan, AS, Bose, N, Underhill, DM, Ma, J, Reyes, CN, Becker, CA

Nature 2011
10779524 Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning

Edelbaum, D, Bergstresser, PR, Morita, A, Shikano, S, Ariizumi, K, Kumamoto, T, Shen, GL, Ritter, R, Xu, S, Takashima, A

J. Biol. Chem. 2000
20193029 Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs

Kerrigan, AM, Brown, GD

Immunol. Rev. 2010
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [plasma membrane]

Orthologous Events
Cite Us!