PKC-delta is activated

Stable Identifier
R-HSA-5607746
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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PKC-delta is activated
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Membrane-bound PKC adopts an open conformation, in which the pseudosubstrate is released from the kinase domain, allowing downstream signaling (Newton 2010).

Literature References
PubMed ID Title Journal Year
15105418 Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta

Stahelin, RV, Digman, MA, Medkova, M, Ananthanarayanan, B, Rafter, JD, Melowic, HR, Cho, W

J. Biol. Chem. 2004
19934406 Protein kinase C: poised to signal

Newton, AC

Am. J. Physiol. Endocrinol. Metab. 2010
Participants
Input
Output
Participant Of
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Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)