26S proteasome processes p-7S-p100:RELB to form p52:RELB

Stable Identifier
R-HSA-5607731
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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26S proteasome processes p-7S-p100:RELB to form p52:RELB
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Once polyubiquitinated, the precursor p100 undergoes 26S proteasome mediated processing to form the mature p52 NF-kB subuunit. Different from complete degradation of other IkB proteins, the proteasome-mediated degradation of p100 only leads to loss of their C-terminal ankyrin repeat regions, leaving intact N-termini, p52 respectively (Amir et al. 2004).
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Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Xenopus tropicalis)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)
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