26S proteasome processes p-7S-p100:RELB to form p52:RELB

Stable Identifier
R-HSA-5607731
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
26S proteasome processes p-7S-p100:RELB to form p52:RELB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once polyubiquitinated, the precursor p100 undergoes 26S proteasome mediated processing to form the mature p52 NF-kB subuunit. Different from complete degradation of other IkB proteins, the proteasome-mediated degradation of p100 only leads to loss of their C-terminal ankyrin repeat regions, leaving intact N-termini, p52 respectively (Amir et al. 2004).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)
Cite Us!