Active NIK phosphorylates IKKA dimer

Stable Identifier
Reaction [transition]
Homo sapiens
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Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B kinase alpha (IKKA) by directly phosphorylating the Ser176 and Ser180 with in the activation loop of IKKA. This phoshorylation is required for IKKA activity (Ling et al. 1998). Besides activating IKKA, NIK also serves as a docking molecule recruiting IKKA to p100 (Xiao et al. 2004).

Literature References
PubMed ID Title Journal Year
17047224 Regulation and function of IKK and IKK-related kinases

Karin, M, Hacker, H

Sci STKE 2006
9520446 NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

Ling, L, Goeddel, DV, Cao, Z

Proc Natl Acad Sci U S A 1998
11520989 Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

Karin, M, Krähn, G, Senftleben, U, Bonizzi, G, Fong, A, Sun, SC, Greten, FR, Hu, Y, Chen, Y, Xiao, G, Cao, Y

Science 2001
Catalyst Activity

protein serine/threonine kinase activity of Active NIK [cytosol]

Orthologous Events
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