Reactome | p-Y753,Y759-PLCG2 [cytosol]

p-Y753,Y759-PLCG2 [cytosol]

Stable Identifier

R-HSA-5607631

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PLCG2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2, PLCG2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O95997 PTTG1

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Literature References

PubMed ID	Title	Journal	Year
15509800	Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2 Kim, YJ, Bae, YS, Rhee, SG, Sekiya, F, Poulin, B	Mol Cell Biol	2004

External Reference Information

External Reference

UniProt:P16885 PLCG2

Gene Names

PLCG2

Chain

chain:1-1265

Reference Genes

BioGPS Gene:5336 PLCG2

COSMIC (genes):PLCG2 PLCG2

CTD Gene:5336 PLCG2

dbSNP Gene:5336 PLCG2

ENSEMBL:ENSG00000197943 PLCG2

HGNC:9066 PLCG2

KEGG:hsa:5336 PLCG2

Monarch:5336 PLCG2

NCBI Gene:5336 PLCG2

OMIM:600220 PLCG2

UCSC:P16885 PLCG2

Reference Transcript

RefSeq:NM_002661.4 PLCG2

Other Identifiers

105369213

1085_s_at

11720244_at

1557993_PM_at

1557993_at

1563263_PM_at

1563263_at

16821326

16821330

16821365

204613_PM_at

204613_at

230917_PM_at

230917_at

3670919

3670920

3670921

3670922

3670923

3670924

3670925

3670926

3670927

3670928

3670935

3670937

3670938

3670941

3670942

3670943

3670948

3670949

3670950

3670955

3670956

3670966

3670968

3670973

3670975

3670976

3670978

3670979

3670980

3670985

3670986

3670990

3670991

3670992

3670993

3670994

3670996

3670997

3670998

3670999

3671000

3671004

3671005

3671006

3671007

3671008

3671009

3671011

3671012

3671013

3671014

3671016

3671017

3671018

3671019

3671020

3671021

3671026

3671029

3671030

3671033

3671034

3671035

3671036

3671037

3671038

3671039

3671040

3671042

3671048

3671049

3671050

3671051

3671052

3671053

3671054

3671055

3671056

3671057

3671065

3671066

3671068

37180_at

46931_at

5336

71846_at

7997453

7997489

86167_at

A_14_P104760

A_14_P126195

A_21_P0008876

A_23_P106675

A_32_P52632

GE476829

GE57955

GE61863

GE632307

GO:0001775

GO:0001784

GO:0001878

GO:0002092

GO:0002223

GO:0002224

GO:0002281

GO:0002316

GO:0002376

GO:0002732

GO:0003824

GO:0004435

GO:0004620

GO:0004629

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006629

GO:0006661

GO:0007165

GO:0008081

GO:0009395

GO:0010468

GO:0010628

GO:0010634

GO:0012501

GO:0016020

GO:0016042

GO:0016055

GO:0016787

GO:0019216

GO:0019722

GO:0019901

GO:0030154

GO:0030168

GO:0030183

GO:0031663

GO:0032481

GO:0032496

GO:0032587

GO:0032733

GO:0032735

GO:0032743

GO:0032747

GO:0032755

GO:0032760

GO:0032959

GO:0035556

GO:0038095

GO:0042113

GO:0043069

GO:0043122

GO:0043226

GO:0043410

GO:0045121

GO:0046488

GO:0048015

GO:0048471

GO:0048678

GO:0050731

GO:0050850

GO:0050852

GO:0050853

GO:0051091

GO:0051092

GO:0051209

GO:0055085

GO:0060100

GO:0060907

GO:0061760

GO:0070062

GO:0070884

GO:0071277

GO:0071396

GO:0097110

GO:0097708

GO:0098542

GO:0140031

GO:0150078

GO:1900227

GO:1902808

GO:1903428

GO:1903721

GO:1990782

GO:1990858

HMNXSV003012305

HMNXSV003023910

HMNXSV003031254

HMNXSV003035070

HMNXSV003039416

HMNXSV003040103

Hs.6179.2.A1_3p_at

Hs.6179.2.A1_3p_x_at

Hs2.382891.1.S1_3p_at

Hs2.382891.1.S1_3p_x_at

Hs2.434339.1.S1_3p_s_at

ILMN_1815719

M37238_s_at

PH_hs_0019237

PH_hs_0026742

RNA144108|snRNA_61_317

TC16000642.hg

TC16000643.hg

TC16000644.hg

TC16001661.hg

TC16001662.hg

TC16001663.hg

g4505870_3p_at

p6539

p6540

p6541

p6542

p6543

p6544

Participates

as a component of

pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Homo sapiens)

as an output of

1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)

as an input of

p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)

Other forms of this molecule

p-PLCG2 [plasma membrane]

PLCG2 [plasma membrane]

p-Y753,Y759,Y1217-PLCG2 [plasma membrane]

PLCG2 [cytosol]

p-4Y-PLCG2 [plasma membrane]

p-Y753,Y759-PLCG2 [plasma membrane]

p-Y-PLCG2 [cytosol]

Inferred To

phospho-sl [cytosol] (Drosophila melanogaster)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Dictyostelium discoideum)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Plasmodium falciparum)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Saccharomyces cerevisiae)

phospho-p-Y753,Y759-PLCG2 [cytosol] (Schizosaccharomyces pombe)

phospho-plcg2 [cytosol] (Xenopus tropicalis)

phospho-Plcg2 [cytosol] (Mus musculus)

phospho-Plcg2 [cytosol] (Rattus norvegicus)

phospho-PLCG2 [cytosol] (Bos taurus)

phospho-PLCG2 [cytosol] (Canis familiaris)

phospho-PLCG2 [cytosol] (Gallus gallus)

phospho-PLCG2 [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 753

Coordinate

753

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 759

Coordinate

759

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002652.2

Guide to Pharmacology - Targets

1408

OpenTargets

ENSG00000197943

ENSEMBL

ENST00000564138, ENSP00000482457

ZINC - Substances

PLCG2_HUMAN

ZINC target

P16885

PRO

P16885

GlyGen

P16885

PDB

2W2X, 2W2W, 2K2J

HPA

ENSG00000197943-PLCG2

Pharos - Targets

P16885

Orphanet

PLCG2

ZINC - Predictions - Purchasable

PLCG2_HUMAN

HMDB Protein

HMDBP00230

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.793	6
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.571	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.536	2
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.525	2
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.508	2
UniProt:O95073-2 FSBP			0.508	2
UniProt:P78381 SLC35A2	6	SLC35A2 F324Lfs25 [Golgi membrane] (R-HSA-5652088) SLC35A2 G8Sfs9 [Golgi membrane] (R-HSA-5652107) SLC35A2 V331I [Golgi membrane] (R-HSA-5652093) SLC35A2 Y145Pfs*76 [Golgi membrane] (R-HSA-5652114) SLC35A2 M1? [Golgi membrane] (R-HSA-5652101) SLC35A2 [Golgi membrane] (R-HSA-735686)	0.499	2
UniProt:O95997 PTTG1	2	K11polyUb-PTTG1 [cytosol] (R-HSA-3095943) PTTG1 [cytosol] (R-HSA-174190)	0.488	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.488	2
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.488	2
UniProt:Q68G74 LHX8			0.488	2
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.488	2
UniProt:Q99645 EPYC			0.488	2

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