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factor VIIIa associates with cell membrane
Stable Identifier
R-HSA-5607043
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor VIIIa associates with cell membrane (Homo sapiens)
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Cleavage of factor VIII light chain promotes a change in the conformation of the C2 domain that facilitates dissociation from VWF and enhances the affinity of factor VIIIa for anionic phospholipid surfaces (Saenko et al. 1998). Membrane-bound thrombin-activated factor VIII (FVIIIa) functions as a cofactor for factor IXa in the factor Xase complex. Factors VIIIa and IXa associate with anionic phospholipid surfaces with high affinity (Gilbert et al. 1990, Mertens & Bertina 1984; Panteleev et al 2004). Kd values ranging from 0.01 to 4.8 nM have been reported for FVIII binding to phospholipids (Gilbert et al. 1990,1992; Spaargaren et al. 1995; Raut et al. 1999; Ahmad et al. 2000). Studies using physiologic surfaces provide evidence for coordinated binding interactions of the enzyme, cofactor and substrate to discrete surface structures. For example, the presence of both (active site-modified) factor IXa and factor X increased both the number and the affinity of binding sites on activated platelets for factor VIIIa (Ahmad et al. 2000). However classical receptors for the constituents of factor Xase have not been identified (Fay 2004).
Literature References
PubMed ID
Title
Journal
Year
9774404
Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets
Greco, NJ
,
Saenko, EL
,
Yakhyaev, AV
,
Scandella, D
J. Biol. Chem.
1998
2104832
Binding of human factor VIII to phospholipid vesicles
Furie, BC
,
Gilbert, GE
,
Furie, B
J. Biol. Chem.
1990
Participants
Input
factor VIIIa [extracellular region]
(Homo sapiens)
Output
factor VIIIa [plasma membrane]
(Homo sapiens)
Participates
as an event of
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
Orthologous Events
factor VIIIa associates with cell membrane (Bos taurus)
factor VIIIa associates with cell membrane (Gallus gallus)
factor VIIIa associates with cell membrane (Mus musculus)
factor VIIIa associates with cell membrane (Rattus norvegicus)
Authored
Jupe, S (2014-07-14)
Reviewed
Mumford, D (2014-09-11)
Created
Jupe, S (2014-07-09)
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