Reactome | factor IXa associates with cell membrane

factor IXa associates with cell membrane

Stable Identifier

R-HSA-5607023

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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factor IXa associates with cell membrane

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Membrane-bound thrombin-activated factor VIII (fVIIIa) functions as a cofactor for factor IXa in the factor Xase complex. Factors VIIIa and IXa associate with anionic phospholipid surfaces with high affinity (Gilbert et al. 1990, Mertens & Bertina 1984, Mertens et al. 1984; Greengard et al. 1986). Studies using physiologic surfaces provide evidence for coordinated binding interactions of the enzyme, cofactor and substrate to discrete surface structures. For example, the presence of both (active site-modified) factor IXa and factor X increased both the number and the affinity of binding sites on activated platelets for factor VIIIa (Ahmad et al. 2000). However classical receptors for the constituents of factor Xase have not been identified (Fay 2004).

Literature References

PubMed ID	Title	Journal	Year
6334516	Binding of human blood-coagulation Factors IXa and X to phospholipid membranes Bertina, RM, Cupers, R, Van Wijngaarden, A, Mertens, K	Biochem. J.	1984
3017409	Binding of coagulation factor XI to washed human platelets Heeb, MJ, Griffin, JH, Ersdal, E, Greengard, JS, Walsh, PN	Biochemistry	1986