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Expression of CD36 (platelet glycoprotein IV, FAT)
Stable Identifier
R-HSA-560517
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
plasma membrane
Synonyms
Induction of Platelet glycoprotein IV (PAS IV, CD36, GPIV) Expression During Adipogenesis
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
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The Platelet glycoprotein IV gene (CD36, PAS IV, GPIV) is transcribed to yield mRNA and the mRNA is translated to yield proteind. The PPARG:RXRA heterodimer bound to fatty acids activates transcription of the Platelet glycoprotein IV (CD36, PAS IV, GPIV) gene. In mouse the Pparg:Rxra heterodimer binds the promoter of the Platelet glycoprotein IV gene (Lefterova et al. 2008).
Literature References
PubMed ID
Title
Journal
Year
16380219
Identification of novel PPARgamma target genes in primary human adipocytes
Dean, NM
,
Koo, S
,
Kim, Y
,
Marcusson, EG
,
Kang, X
,
Perera, RJ
,
White, N
Gene
2006
Participants
Input
CD36 gene [nucleoplasm]
(Homo sapiens)
Output
4xPalmC-CD36 [plasma membrane]
(Homo sapiens)
Participates
as an event of
PPARA activates gene expression (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
This event is regulated
Positively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]
(Homo sapiens)
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm]
(Homo sapiens)
Authored
May, B (2010-03-23)
Reviewed
Sethi, JK (2011-02-10)
Kersten, S (2009-06-08)
D'Eustachio, P (2009-05-27)
Created
May, B (2010-03-24)
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