Expression of CD36 (platelet glycoprotein IV, FAT)

Stable Identifier
R-HSA-560517
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
Synonyms
Induction of Platelet glycoprotein IV (PAS IV, CD36, GPIV) Expression During Adipogenesis
ReviewStatus
5/5
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Expression of CD36 (platelet glycoprotein IV, FAT)
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The Platelet glycoprotein IV gene (CD36, PAS IV, GPIV) is transcribed to yield mRNA and the mRNA is translated to yield proteind.

The PPARG:RXRA heterodimer bound to fatty acids activates transcription of the Platelet glycoprotein IV (CD36, PAS IV, GPIV) gene. In mouse the Pparg:Rxra heterodimer binds the promoter of the Platelet glycoprotein IV gene (Lefterova et al. 2008).

Literature References
PubMed ID Title Journal Year
16380219 Identification of novel PPARgamma target genes in primary human adipocytes

Dean, NM, Koo, S, Kim, Y, Marcusson, EG, Kang, X, Perera, RJ, White, N

Gene 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-03-23)
Reviewed
Sethi, JK  (2011-02-10)
Kersten, S  (2009-06-08)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-24)
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