Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)

Stable Identifier
R-HSA-560472
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
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The PPARG:RXRA heterodimer bound to fatty acids activates transcription of the PEPCK-C gene. In mouse the Pparg:Rxra heterodimer binds the promoter of the Pepck-c gene (Leftovera et al. 2008). The PEPCK-C gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
16380219 Identification of novel PPARgamma target genes in primary human adipocytes

Dean, NM, Koo, S, Kim, Y, Marcusson, EG, Kang, X, Perera, RJ, White, N

Gene 2006
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-03-23)
Reviewed
Sethi, JK  (2011-02-10)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-24)
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