TPMT Y240C [cytosol]

Stable Identifier
R-HSA-5603343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Thiopurine S-methyltransferase, TPMT_HUMAN
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P51580 TPMT
Gene Names
TPMT
Chain
chain:1-245
Reference Genes
BioGPS Gene:7172 TPMT
COSMIC (genes):TPMT TPMT
CTD Gene:7172 TPMT
dbSNP Gene:7172 TPMT
ENSEMBL:ENSG00000137364 TPMT
HGNC:12014 TPMT
KEGG:hsa:7172 TPMT
Monarch:7172 TPMT
NCBI Gene:7172 TPMT
OMIM:187680 TPMT
UCSC:P51580 TPMT
Reference Transcript
Other Identifiers
11727822_a_at
11727823_x_at
11727824_at
11727825_x_at
17015975
203671_PM_at
203671_at
203672_PM_x_at
203672_x_at
2944026
2944027
2944028
2944029
2944030
2944031
2944034
2944035
2944037
2944038
2944040
2944042
2944043
2944044
2944045
2944050
32810_at
3787362
3787364
7172
8124134
A_23_P214108
A_24_P397498
A_33_P3317321
GE62974
GO:0003824
GO:0005515
GO:0005737
GO:0005829
GO:0006139
GO:0006805
GO:0008119
GO:0008168
GO:0008757
GO:0016740
GO:0032259
GO:0042178
GO:1904047
HMNXSV003028526
Hs.296922.0.A4_3p_at
ILMN_1740185
PH_hs_0024285
S62904_s_at
TC06001301.hg
U12387_s_at
g805083_3p_a_at
Participates
as a member of
Other forms of this molecule
TPMT A167G [cytosol]
TPMT A80P [cytosol]
TPMT A154T [cytosol]
TPMT [cytosol]
Modified Residues
Name
L-tyrosine 240 replaced with L-cysteine
Coordinate
240
PsiMod
L-tyrosine removal [MOD:01649]
A protein modification that effectively removes or replaces an L-tyrosine.
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
Disease
Name Identifier Synonyms
inherited metabolic disorder DOID:655 Metabolic hereditary disorder, Inborn Errors of Metabolism, inborn metabolism disorder
Cross References
ENSEMBL
OpenTargets
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Metabolites
IntEnz
HPA
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (3)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P61981 YWHAG  1 0.556 3
 UniProt:Q8TAP4-4 LMO3      0.556 3
 UniProt:Q15047-2 SETDB1      0.556 3
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