GCLC P185L [cytosol]

Stable Identifier
R-HSA-5602975
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glutamate--cysteine ligase heavy chain, gamma-glutamylcysteine heavy chain
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P48506 GCLC
Gene Names
GCLC, GLCL, GLCLC
Chain
chain:1-637
Reference Genes
BioGPS Gene:2729 GCLC
COSMIC (genes):GCLC GCLC
CTD Gene:2729 GCLC
dbSNP Gene:2729 GCLC
ENSEMBL:ENSG00000001084 GCLC
HGNC:4311 GCLC
KEGG Gene (Homo sapiens):2729 GCLC
Monarch:2729 GCLC
NCBI Gene:2729 GCLC
OMIM:606857 GCLC
UCSC:P48506 GCLC
Reference Transcript
Other Identifiers
0001990066
00270+6.3.2.2
00480+6.3.2.2
11729218_a_at
11750770_a_at
11754931_a_at
202922_at
202923_s_at
2729
2957706
2957707
2957708
2957709
2957710
2957712
2957714
2957715
2957717
2957722
2957724
2957725
2957727
2957730
2957732
2957737
2957738
2957741
2957742
2957750
2957751
2957752
2957767
2957768
2957769
31850_at
49163_at
52591_s_at
52592_r_at
56626_r_at
8127158
A0A0C4DGB2
A0A2R8Y648
A0A2R8YEL6
A_23_P145114
AAA58499
AAC41751
AAD18031
AAH22487
AAH39894
AAV31778
AB262176
AF118846
AK313480
AL033397
AY780794
B4E2I4
BAE97618
BAG36264
BC022487
BC039894
CAB009569
CCDS4952
CH471081
D6RGF8
E1CEI4
EAX04425
EAX04426
ENSG00000001084
ENSP00000497574
ENST00000229416.10
ENST00000650454
ENST00000650454.1
EntrezGene:2729
EntrezGene:GCLC
g4557624_3p_a_at
GCLC
GCLC-214
GE58133
GO:0000166
GO:0000287
GO:0003013
GO:0003674
GO:0003824
GO:0004357
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006464
GO:0006520
GO:0006534
GO:0006536
GO:0006749
GO:0006750
GO:0006790
GO:0006810
GO:0006950
GO:0006979
GO:0007005
GO:0007165
GO:0007568
GO:0007584
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0009408
GO:0009410
GO:0009725
GO:0014823
GO:0016595
GO:0016874
GO:0017109
GO:0019852
GO:0031397
GO:0032436
GO:0032869
GO:0032991
GO:0034641
GO:0035729
GO:0042592
GO:0043066
GO:0043167
GO:0043226
GO:0043524
GO:0043531
GO:0044281
GO:0044344
GO:0044752
GO:0045454
GO:0045892
GO:0046685
GO:0046686
GO:0046982
GO:0050662
GO:0051186
GO:0051409
GO:0051900
GO:0061024
GO:0070555
GO:0071260
GO:0071333
GO:0071372
GO:0097069
GO:0097746
GO:1901029
GO:2000490
GO:2001237
HGNC:4311
HPA036359
HPA036360
Hs.151393.0.S2_3p_at
ILMN_1730575
ILMN_2215194
IPR004308
IPR014746
L39773
LRG_1166
M90656
M90656_at
MIM:230450
MIM:606857
MIM:608446
NM_001498
NP_001489
PF03074
Q14TF0
TC06004051.hg
UPI000000D970
Participant Of
hasMember
Other forms of this molecule
GCLC H370L [cytosol]
GCLC R127C [cytosol]
GCLC [cytosol]
Modified Residues
Name
L-proline 158 replaced with L-leucine
Coordinate
158
PsiMod
L-proline removal [MOD:01645]
A protein modification that effectively removes or replaces an L-proline.
L-leucine residue [MOD:00020]
A protein modification that effectively converts a source amino acid residue to an L-leucine.
Disease
Name Identifier Synonyms
hemolytic anemia 583 Hemolytic anemias (disorder), Hemolytic anemia (disorder), Hemolytic anemias NOS (disorder), hemolytic anemia, ANEMIA HEMOLYTIC
Cross References
RefSeq
OpenTargets
ZINC - Substances
GeneCards
ZINC target
PRO
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein