Defective MyD88 does not bind MAL(TIRAP):TLR2/4

Stable Identifier
R-HSA-5602606
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Defective MyD88 does not bind MAL(TIRAP):TLR2/4
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The sorting MyD88 adaprtor-like (MAL or TIRAP) normally recruits MyD88 to activated TLR2 and TLR4 receptor complexes (Horng T et al. 2002; Verstak B et al. 2009). MyD88 interacts with MAL (TIRAP) via their TIR domains and activates a downstream signaling pathway mediated by TLR2 and TLR4 (Ohnishi H et al. 2009). A GST pull-down assay showed that defective MyD88 R196C variant loses its ability to bind to MAL (Yamamoto T et al. 2014).
Literature References
PubMed ID Title Journal Year
24316379 Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

Kondo, N, Shirakawa, M, Ohnishi, H, Tochio, H, Kato, Z, Tsutsumi, N, Kubota, K, Yamamoto, T

Mol. Immunol. 2014
19506249 Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

Kondo, N, Shirakawa, M, Hiroaki, H, Ohnishi, H, Tochio, H, Kato, Z, Orii, KE, Kimura, T, Li, A

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Input
Participates
as an event of
Normal reaction
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
Functional status

Loss of function of MyD88 R196C [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
primary immunodeficiency disease DOID:612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Authored
Shamovsky, V  (2014-05-21)
Reviewed
D'Eustachio, P  (2014-09-06)
McDonald, DR  (2015-02-15)
Created
Shamovsky, V  (2014-06-24)
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