TRAF3 deficiency - HSE

Stable Identifier
R-HSA-5602571
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

TNF Receptor Associated Factor 3 (TRAF3) is a cytoplasmic adaptor protein utilized by the tumor necrosis factor receptor superfamily and toll-like receptors (TLRs). TRAF3 deficiency is thought to mimic the previously reported TLR3 deficiency in terms of susceptibility to herpes simplex virus type 1 (HSV1) encephalitis (HSE) via impaired TLR3-mediated immunity against HSV1 infection of central nervous system (CNS) (Pérez de Diego R et al. 2010; Guo Y et al. 2011).

Literature References
PubMed ID Title Journal Year
20832341 Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

Pérez de Diego, R, Sancho-Shimizu, V, Lorenzo, L, Puel, A, Plancoulaine, S, Picard, C, Herman, M, Cardon, A, Durandy, A, Bustamante, J, Vallabhapurapu, S, Bravo, J, Warnatz, K, Chaix, Y, Cascarrigny, F, Lebon, P, Rozenberg, F, Karin, M, Tardieu, M, Al-Muhsen, S, Jouanguy, E, Zhang, SY, Abel, L, Casanova, JL

Immunity 2010
Participants
Participant Of
Disease
Name Identifier Synonyms
primary immunodeficiency disease 612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Authored
Reviewed
Created
Cite Us!