TRAF3 deficiency - HSE

Stable Identifier
R-HSA-5602571
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

TNF Receptor Associated Factor 3 (TRAF3) is a cytoplasmic adaptor protein utilized by the tumor necrosis factor receptor superfamily and toll-like receptors (TLRs). TRAF3 deficiency is thought to mimic the previously reported TLR3 deficiency in terms of susceptibility to herpes simplex virus type 1 (HSV1) encephalitis (HSE) via impaired TLR3-mediated immunity against HSV1 infection of central nervous system (CNS) (Pérez de Diego R et al. 2010; Guo Y et al. 2011).

Literature References
PubMed ID Title Journal Year
20832341 Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

Abel, L, Lebon, P, Bravo, J, Al-Muhsen, S, Pérez de Diego, R, Herman, M, Chaix, Y, Lorenzo, L, Jouanguy, E, Warnatz, K, Plancoulaine, S, Vallabhapurapu, S, Puel, A, Picard, C, Bustamante, J, Zhang, SY, Cardon, A, Cascarrigny, F, Rozenberg, F, Durandy, A, Sancho-Shimizu, V, Casanova, JL, Karin, M, Tardieu, M

Immunity 2010
Participants
Participates
Disease
Name Identifier Synonyms
primary immunodeficiency disease DOID:612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Authored
Reviewed
Created
Cite Us!