TICAM1 deficiency - HSE

Stable Identifier
R-HSA-5602566
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TICAM1 deficiency - HSE
Click the image above or here to open this pathway in the Pathway Browser
Inborn errors of interferon immunity due to defects in toll like receptor 3 (TLR3)-mediated signaling underlie pathogenesis of herpes simplex virus type 1 (HSV1) encephalitis (HSE) in some children (Netea MG et al. 2012). Autosomal dominant (AD) and recessive (AR) deficiencies of (TIR) domain-containing adaptor inducing IFN-beta (TRIF or TICAM1) are also associated with impaired IFN production and predisposition to HSE in the course of primary infection by HSV1 (Sancho-Shimizu V et al. 2011).
Literature References
PubMed ID Title Journal Year
22105173 Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

Alkhamis, N, Abel, L, Halwani, R, Ghadiri, A, Lebon, P, Al-Muhsen, S, Alangari, A, Lorenzo, L, Maluenda, J, Plancoulaine, S, Mahvelati, F, Cardon, A, Rozenberg, F, Sancho-Shimizu, V, Al-Makadma, AS, Ciancanelli, M, Chaussabel, D, Fabrega, S, Rezaei, N, AlSum, Z, Pérez de Diego, R, Herman, M, Seya, T, Jouanguy, E, Matsumoto, M, Puel, A, Picard, C, Boucherit, S, Tatematsu, M, Zhang, SY, Guo, Y, Casanova, JL, Israelsson, E, Tardieu, M

J. Clin. Invest. 2011
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
primary immunodeficiency disease DOID:612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Authored
Shamovsky, V  (2014-05-21)
Reviewed
D'Eustachio, P  (2014-09-06)
McDonald, DR  (2015-02-15)
Created
Shamovsky, V  (2014-06-24)
Cite Us!