RNA polymerase II polymerizes primary piRNA transcript

Stable Identifier
R-HSA-5601926
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
piRNA locus is transcribed
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As inferred from experiments with mouse homologs, primary piRNA transcripts originate from multiple copy transposable elements and unique copy non-coding RNAs and mRNAs. As male germ cells progress from fetus to adult, the composition of piRNAs shifts from transposons to unique copy sequences (reviewed in Bortvin 2013). Computational analyses have identified 161 to 242 piRNA clusters and many other smaller piRNA hotspots in the mouse genome (Aravin et al. 2008, Rosenkranz and Zischler 2012, Jung et al. 2014). About 18% of pre-pachytene piRNAs in mouse originate from mRNAs encoding proteins (Aravin et al. 2008). Likewise 235 to 368 piRNA clusters were identified in the human genome (Rosenkranz and Zischler 2012, Gould et al. 2012, Yang et al. 2013, Jung et al. 2014).
As inferred from the mouse homolog, the MYBL1 (A-MYB) transcription factor drives transcription of both piRNA precursors and mRNAs encoding PIWI family proteins.

Literature References
PubMed ID Title Journal Year
23056369 Selective constraint on copy number variation in human piwi-interacting RNA Loci

Lukic, S, Chen, KC, Gould, DW

PLoS ONE 2012
18922463 A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

Bourc'his, D, Toth, KF, Hannon, GJ, Bestor, T, Pezic, D, Aravin, AA, Sachidanandam, R, Schaefer, C

Mol. Cell 2008
24656595 piClust: A density based piRNA clustering algorithm

Jung, I, Park, JC, Kim, S

Comput Biol Chem 2014
23826142 MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing

Yu, D, Hua, J, Ye, N, Zhang, Z, Shi, Q, Zhang, H, Zhang, Y, Cooke, HJ, Yang, Q, Wang, L, Xu, B

PLoS ONE 2013
22233380 proTRAC--a software for probabilistic piRNA cluster detection, visualization and analysis

Zischler, H, Rosenkranz, D

BMC Bioinformatics 2012
Participants
Participates
Event Information
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]

This event is regulated
Positively by
Inferred From
Authored
Reviewed
Created
Cite Us!