Primary piRNA transcript translocates from nucleoplasm to cytosol

Stable Identifier
Reaction [omitted]
Homo sapiens
Transport of pre-piRNA to cytosol
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Primary (unprocessed) transcripts of piRNAs are transported from the nucleus to the cytosol by an unknown mechanism. Studies with Drosophila indicate that Uap56, Nxt1, Nxf2, Nup154, and Nup43 may be involved in exporting piRNA precursors from the nucleus (Zhang et al. 2012, Muerdter et al. 2013, Handler et al. 2013).

Literature References
PubMed ID Title Journal Year
23665231 The genetic makeup of the Drosophila piRNA pathway

Meixner, K, Lauss, K, Gruber, FS, Pizka, M, Handler, D, Brennecke, J, Schmied, C

Mol. Cell 2013
23665228 A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila

Guzzardo, PM, Fekete, R, Luo, Y, Hannon, GJ, Chen, C, Yu, Y, Muerdter, F, Gillis, J

Mol. Cell 2013
23141543 UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery

Zhang, F, Theurkauf, WE, Schultz, N, Zhang, Z, Weng, Z, Davis, I, Wang, J, Meignin, C, Zamore, PD, Vreven, T, Koppetsch, BS, Xu, J

Cell 2012
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