Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA

Stable Identifier
R-HSA-5601910
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA
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As inferred from homologs in mouse, PIWIL2 (HILI in human, homolog of MILI in mouse) bound to a piRNA cleaves target RNAs complementary to the piRNA. The cleaved RNA can either be transferred to another PIWIL2 as part of the "ping pong cycle" that generates secondary piRNAs or the cleaved RNA can be transferred to PIWIL4, which then transits to the nucleus to transcriptionally silence loci complementary to the piRNA.
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Catalyst Activity

RNA endonuclease activity of 6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol]

Physical Entity
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
Activity
RNA endonuclease activity (GO:0004521)
Inferred From
Complexed Piwil2:2'-O-methyl-piRNA cleaves transposon RNA (Mus musculus)
Authored
May, B  (2014-06-14)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-06-15)
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