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6xMeR-PIWIL2 [cytosol]
Stable Identifier
R-HSA-5601894
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Piwi-like protein 2, PIWL2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Complexed PIWIL2 binds pre-piRNA (Homo sapiens)
6xMeR-PIWIL2:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:pre-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:cleaved transposon RNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:cleaved transposon RNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
Unknown nuclease cleaves pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12 (Homo sapiens)
6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:pre-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TC59 PIWIL2
Gene Names
PIWIL2, HILI
Chain
chain:1-973
Reference Genes
BioGPS Gene:55124 PIWIL2
COSMIC (genes):PIWIL2 PIWIL2
CTD Gene:55124 PIWIL2
dbSNP Gene:55124 PIWIL2
ENSEMBL:ENSG00000197181 PIWIL2
HGNC:17644 PIWIL2
KEGG:hsa:55124 PIWIL2
Monarch:55124 PIWIL2
NCBI Gene:55124 PIWIL2
OMIM:610312 PIWIL2
UCSC:Q8TC59 PIWIL2
Reference Transcript
RefSeq:NM_001135721.1 PIWIL2
RefSeq:NM_018068.3 PIWIL2
RefSeq:NM_001330480.1 PIWIL2
Other Identifiers
11732686_x_at
11737806_a_at
17066573
220686_3p_s_at
220686_PM_s_at
220686_s_at
239303_PM_at
239303_at
2441880
3089317
3089318
3089319
3089320
3089321
3089322
3089323
3089324
3089325
3089326
3089327
3089328
3089331
3089332
3089334
3089337
3089339
3089340
3089341
3089343
3089344
3089345
3089346
3089353
3089354
3089355
3089356
3089357
3089358
3089359
3114207
3559864
3696292
55124
57285_at
81123_r_at
8145097
A_14_P134353
A_23_P253074
A_32_P208654
GE84437
GO:0003676
GO:0003723
GO:0003729
GO:0003824
GO:0004519
GO:0004521
GO:0005515
GO:0005634
GO:0005737
GO:0006325
GO:0006417
GO:0007283
GO:0010370
GO:0016787
GO:0022414
GO:0030154
GO:0030718
GO:0031047
GO:0033391
GO:0034584
GO:0034587
GO:0042754
GO:0043186
GO:0043226
GO:0046872
GO:0048477
GO:0048511
GO:0048856
GO:0051321
GO:0060903
GO:0061980
GO:0071546
GO:0097433
GO:0140098
GO:0140965
GO:0140991
GO:0141005
GO:0141006
GO:0141008
GO:0141196
GO:1990923
GO:2000767
HMNXSV003019382
HMNXSV003039141
Hs.97814.0.A1_3p_at
ILMN_1711818
ILMN_1755350
ILMN_1772147
PH_hs_0014120
TC08000169.hg
g8922369_3p_a_at
Participates
as a component of
6xMeR-PIWIL2:cleaved transposon RNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] (Homo sapiens)
6xMeR-PIWIL2:pre-piRNA [cytosol] (Homo sapiens)
6xMeR-PIWIL2:piRNA [cytosol] (Homo sapiens)
PIWIL2:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
Inferred From
6xMeR-Piwil2 [cytosol]
(Mus musculus)
Modified Residues
Name
symmetric dimethyl-L-arginine at 76
Coordinate
76
PsiMod Name
symmetric dimethyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.
Name
omega-N-methyl-L-arginine at 97
Coordinate
97
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Name
symmetric dimethyl-L-arginine at 102
Coordinate
102
PsiMod Name
symmetric dimethyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.
Name
symmetric dimethyl-L-arginine at 165
Coordinate
165
PsiMod Name
symmetric dimethyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.
Name
symmetric dimethyl-L-arginine at 551
Coordinate
551
PsiMod Name
symmetric dimethyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.
Name
symmetric dimethyl-L-arginine at 47
Coordinate
47
PsiMod Name
symmetric dimethyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.
Cross References
ENSEMBL
ENSP00000428267
,
ENSP00000478103
,
ENST00000356766
,
ENSG00000197181
,
ENSP00000349208
,
ENSP00000406956
,
ENST00000521356
,
ENST00000611073
,
ENST00000454009
OpenTargets
ENSG00000197181
GeneCards
PIWIL2
HPA
ENSG00000197181-PIWIL2
PRO
Q8TC59
Pharos - Targets
Q8TC59
PDB
3O7X
,
3QIR
,
7YFX
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