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4xMeR-PIWIL1 [cytosol]
Stable Identifier
R-HSA-5601891
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Piwi-like protein 1, PIWL1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Complexed PIWIL1 binds pre-piRNA (Homo sapiens)
4xMeR-PIWIL1:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1 [cytosol] (Homo sapiens)
4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1:pre-piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1 [cytosol] (Homo sapiens)
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)
4xMeR-PIWIL1:2'-O-methyl-piRNA:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1 [cytosol] (Homo sapiens)
4xMeR-PIWIL1:piRNA:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1:piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1 [cytosol] (Homo sapiens)
Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH (Homo sapiens)
4xMeR-PIWIL1:piRNA:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1:piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1 [cytosol] (Homo sapiens)
4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1:pre-piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96J94 PIWIL1
Gene Names
PIWIL1, HIWI
Chain
chain:1-861
Reference Genes
BioGPS Gene:9271 PIWIL1
COSMIC (genes):PIWIL1 PIWIL1
CTD Gene:9271 PIWIL1
dbSNP Gene:9271 PIWIL1
ENSEMBL:ENSG00000125207 PIWIL1
HGNC:9007 PIWIL1
Monarch:9271 PIWIL1
NCBI Gene:9271 PIWIL1
OMIM:605571 PIWIL1
UCSC:Q96J94 PIWIL1
Reference Transcript
RefSeq:XM_011539003.2 PIWIL1
RefSeq:XM_011539004.2 PIWIL1
RefSeq:NM_004764.4 PIWIL1
RefSeq:NM_001190971.1 PIWIL1
RefSeq:XM_011539002.2 PIWIL1
Other Identifiers
11728487_at
16759159
214868_PM_at
214868_at
3437831
3437832
3437833
3437836
3437837
3437838
3437840
3437841
3437842
3437843
3437844
3437845
3437846
3437847
3437848
3437849
3437850
3437853
3437855
3437856
3437857
3437858
3437860
3437861
3437862
3437863
3437864
3437865
3437868
3437869
3437871
3437872
3437873
3437874
35901_at
76330_r_at
7959856
9271
A_14_P109064
A_14_P115275
A_14_P200785
A_23_P116741
GE472658
GO:0003676
GO:0003723
GO:0003727
GO:0003729
GO:0003824
GO:0004519
GO:0004521
GO:0005515
GO:0005634
GO:0005737
GO:0006325
GO:0006417
GO:0007283
GO:0007286
GO:0016787
GO:0019901
GO:0022414
GO:0030154
GO:0031047
GO:0033391
GO:0034584
GO:0034587
GO:0035092
GO:0043186
GO:0043226
GO:0046872
GO:0048856
GO:0051321
GO:0061980
GO:0097433
GO:0140098
GO:0140262
GO:0140990
GO:0140991
GO:0141006
HMNXSV003024461
Hs.194712.0.S1_3p_at
Hs.194712.0.S1_3p_x_at
ILMN_1701220
PH_hs_0024659
TC12001034.hg
Participates
as a component of
4xMeR-PIWIL1:TDRD6:TDRKH [cytosol] (Homo sapiens)
4xMeR-PIWIL1:pre-piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1:2'-O-methyl-piRNA [cytosol] (Homo sapiens)
4xMeR-PIWIL1:piRNA [cytosol] (Homo sapiens)
Inferred From
4xMeR-Piwil1 [cytosol]
(Mus musculus)
Modified Residues
Name
symmetric dimethyl-L-arginine at 14
Coordinate
14
PsiMod Name
symmetric dimethyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.
Name
omega-N-methyl-L-arginine at 49
Coordinate
49
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Name
omega-N-methyl-L-arginine at 53
Coordinate
53
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Name
omega-N-methyl-L-arginine at 370
Coordinate
370
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Cross References
ENSEMBL
ENST00000613226
,
ENSP00000487688
,
ENSP00000245255
,
ENSP00000481042
,
ENST00000245255
,
ENST00000632888
OpenTargets
ENSG00000125207
HPA
ENSG00000125207-PIWIL1
PRO
Q96J94
Pharos - Targets
Q96J94
PDB
3O6E
,
3O7V
,
2L5D
,
2L5C
,
3O3I
,
6PI7
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q9Y2W6 TDRKH
1
TDRKH [cytosol]
(R-HSA-5608255)
0.527
2
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.499
2
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