PLD6 dimer cleaves primary piRNA transcript to pre-piRNA

Stable Identifier
R-HSA-5601887
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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PLD6 dimer cleaves primary piRNA transcript to pre-piRNA
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As inferred from homologs in Drosophila and mouse, PLD6 (MitoPLD) located on the cytoplasmic face of the mitochondrial outer membrane makes the first endonucleolytic cleavage of primary piRNA transcripts. The cleavage yields a 5' phosphate and a 3' hydroxyl. Cleavage is believed to precede loading into PIWIL1 (HIWI, MIWI) or PIWIL2 (HILI, MILI). Most mature piRNAs have uracil at the 5' end. This appears to be due to selective binding by PIWI proteins rather than selective cleavage (reviewed in Bortvin 2013).
Literature References
PubMed ID Title Journal Year
23980886 PIWI-interacting RNAs (piRNAs) - a mouse testis perspective

Bortvin, A

Biochemistry Mosc. 2013
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Catalyst Activity

RNA endonuclease activity of PLD6 dimer [mitochondrial outer membrane]

Physical Entity
PLD6 dimer [mitochondrial outer membrane] (Homo sapiens)
Activity
RNA endonuclease activity (GO:0004521)
Inferred From
Pld6 dimer cleaves primary piRNA transcript to pre-piRNA (Mus musculus)
Authored
May, B  (2014-06-14)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-06-15)
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