Complexed PIWIL4 binds cleaved transposon RNA

Stable Identifier
R-HSA-5601883
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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RNA cleaved by PIWIL2:piRNA is transferred to PIWIL4 (HIWI2 in human, MIWI2 in mouse). The reaction requires MAEL and is enhanced by the chaperone activity of FKBP6:HSP90. PIWIL4, TDRD9, and MAEL are located in piP bodies, a type of nuage (electron-dense perinuclear material). PIWIL4 and PIWIL2 are in separate nuages.

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