Complexed PIWIL4 binds cleaved transposon RNA

Stable Identifier
R-HSA-5601883
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Complexed PIWIL4 binds cleaved transposon RNA
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RNA cleaved by PIWIL2:piRNA is transferred to PIWIL4 (HIWI2 in human, MIWI2 in mouse). The reaction requires MAEL and is enhanced by the chaperone activity of FKBP6:HSP90. PIWIL4, TDRD9, and MAEL are located in piP bodies, a type of nuage (electron-dense perinuclear material). PIWIL4 and PIWIL2 are in separate nuages.

Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FKBP6:HSP90AA1 [cytosol] (Homo sapiens)
Inferred From
Complexed Piwil4 binds cleaved transposon RNA (Mus musculus)
Authored
May, B  (2014-06-14)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-06-15)
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