Reactome | CYP17A1 W17* [endoplasmic reticulum membrane]

CYP17A1 W17* [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5601860

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Steroid 17alpha-monooxygenase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P05093 CYP17A1

Gene Names

CYP17A1, CYP17, S17AH

Chain

chain:1-508

Reference Genes

BioGPS Gene:1586 CYP17A1

COSMIC (genes):CYP17A1 CYP17A1

CTD Gene:1586 CYP17A1

dbSNP Gene:1586 CYP17A1

ENSEMBL:ENSG00000148795.7 CYP17A1

HGNC:2593 CYP17A1

KEGG Gene (Homo sapiens):1586 CYP17A1

Monarch:1586 CYP17A1

NCBI Gene:1586 CYP17A1

OMIM:609300 CYP17A1

Reference Transcript

RefSeq:NM_000102.3 CYP17A1

Other Identifiers

0000770095

11723413_at

1586

16717970

205502_PM_at

205502_at

31789_at

3304524

3304525

3304526

3304527

3304528

3304531

3304532

3304533

3304535

3304536

3304538

3304539

3304541

3304542

3304543

586_s_at

7936050

A_24_P52597

A_33_P3376478

GE57830

GO:0004497

GO:0004508

GO:0005506

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006702

GO:0006704

GO:0007548

GO:0008202

GO:0016020

GO:0016491

GO:0016705

GO:0016829

GO:0019825

GO:0020037

GO:0022414

GO:0030424

GO:0042446

GO:0042448

GO:0043025

GO:0043226

GO:0043231

GO:0046872

GO:0047442

HMNXSV003034080

ILMN_1760554

M31153_at

PH_hs_0025651

PH_hs_0036009

TC10001625.hg

g4503194_3p_at

Participates

as a member of

CYP17A1 mutants [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

CYP17A1 R347H [endoplasmic reticulum membrane]

CYP17A1 R96W [endoplasmic reticulum membrane]

CYP17A1 S106P [endoplasmic reticulum membrane]

CYP17A1 R358Q [endoplasmic reticulum membrane]

CYP17A1 R96Q [endoplasmic reticulum membrane]

CYP17A1 W406R [endoplasmic reticulum membrane]

CYP17A1 R362C [endoplasmic reticulum membrane]

CYP17A1 [endoplasmic reticulum membrane]

Modified Residues

Name

Nonsense mutation at L-tryptophan 17

Coordinate

PsiMod

L-tryptophan removal [MOD:01648]

A protein modification that effectively removes or replaces an L-tryptophan.

Disease

Name	Identifier	Synonyms
adrenal gland disease	DOID:9553

Cross References

RefSeq

NP_000093.1

ZINC - World Drugs

CP17A_HUMAN

Guide to Pharmacology - Targets

1361

OpenTargets

ENSG00000148795

ZINC - FDA approved

CP17A_HUMAN

ZINC - Substances

CP17A_HUMAN

ZINC target

P05093

ZINC - Biogenic

CP17A_HUMAN

PRO

P05093

PDB

4NKV, 6CIR, 6WR1, 6WW0, 4NKZ, 5IRQ, 3SWZ, 4NKY, 6CIZ, 5IRV, 6CHI, 4NKX, 6WR0, 5UYS, 4NKW, 3RUK

ZINC - Investigational

CP17A_HUMAN

ZINC - Metabolites

CP17A_HUMAN

GeneCards

P05093

HPA

ENSG00000148795-CYP17A1

Ensembl

ENSG00000148795, ENST00000369887, ENSP00000358903

Pharos - Targets

P05093

Orphanet

15836

ZINC - Predictions - Purchasable

CP17A_HUMAN

HMDB Protein

HMDBP01043