Metabolic disorders of biological oxidation enzymes

Stable Identifier
R-HSA-5579029
DOI
10.3180/REACT_267615.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolic disorders of biological oxidation enzymes
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The ability to process xenobiotica and many endogenous compounds is called biotransformation and is catalysed by enzymes mainly in the liver of higher organisms but also a number of other organs such as kidneys, gut and lungs. Metabolism occurs in two stages; phase 1 functionalisation and phase 2 conjugation. Defects in enzymes in these two phases can lead to disease (Nebert et al. 2013, Pikuleva & Waterman 2013, Zanger & Schwab 2013, Mudd 2013, Messenger et al. 2013, Aoyama & Nakaki 2013, Shih 2004, Millington 2013, Azimi et al. 2014, Sticova & Jirsa 2013).
Literature References
PubMed ID Title Journal Year
23333322 Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

Schwab, M, Zanger, UM

Pharmacol. Ther. 2013
21308989 Hypermethioninemias of genetic and non-genetic origin: A review

Mudd, SH

Am J Med Genet C Semin Med Genet 2011
24145751 Impaired glutathione synthesis in neurodegeneration

Nakaki, T, Aoyama, K

Int J Mol Sci 2013
23632021 Cytochromes p450: roles in diseases

Pikuleva, IA, Waterman, MR

J. Biol. Chem. 2013
23252752 Obesity, genetics and the skin

Millington, GW

Clin. Exp. Dermatol. 2013
24307925 A Review of Trimethylaminuria: (Fish Odor Syndrome)

Messenger, J, Bechtel, M, Clark, S, Massick, S

J Clin Aesthet Dermatol 2013
24151358 New insights in bilirubin metabolism and their clinical implications

Jirsa, M, Sticová, E

World J. Gastroenterol. 2013
23297354 Human cytochromes P450 in health and disease

Nebert, DW, Miller, WL, Wikvall, K

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2013
14697877 Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B

Shih, JC

Neurotoxicology 2004
24734162 Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia

Azimi, F, Azad, M, Mortazavi, Y, Jafariyan, M, Khatami, S

Iran J Ped Hematol Oncol 2014
Participants
Events
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as an event of
Disease
Name Identifier Synonyms
inherited metabolic disorder DOID:655 Metabolic hereditary disorder, Inborn Errors of Metabolism, inborn metabolism disorder
Authored
Jassal, B  (2014-06-06)
Reviewed
Nakaki, T  (2014-11-03)
Created
Jassal, B  (2014-06-06)
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