Metabolic disorders of biological oxidation enzymes

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
Click the image above or here to open this pathway in the Pathway Browser
The ability to process xenobiotica and many endogenous compounds is called biotransformation and is catalysed by enzymes mainly in the liver of higher organisms but also a number of other organs such as kidneys, gut and lungs. Metabolism occurs in two stages; phase 1 functionalisation and phase 2 conjugation. Defects in enzymes in these two phases can lead to disease (Nebert et al. 2013, Pikuleva & Waterman 2013, Zanger & Schwab 2013, Mudd 2013, Messenger et al. 2013, Aoyama & Nakaki 2013, Shih 2004, Millington 2013, Azimi et al. 2014, Sticova & Jirsa 2013).
Literature References
PubMed ID Title Journal Year
23333322 Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

Schwab, M, Zanger, UM

Pharmacol. Ther. 2013
21308989 Hypermethioninemias of genetic and non-genetic origin: A review

Mudd, SH

Am J Med Genet C Semin Med Genet 2011
24145751 Impaired glutathione synthesis in neurodegeneration

Nakaki, T, Aoyama, K

Int J Mol Sci 2013
23632021 Cytochromes p450: roles in diseases

Pikuleva, IA, Waterman, MR

J. Biol. Chem. 2013
23252752 Obesity, genetics and the skin

Millington, GW

Clin. Exp. Dermatol. 2013
24307925 A Review of Trimethylaminuria: (Fish Odor Syndrome)

Messenger, J, Bechtel, M, Clark, S, Massick, S

J Clin Aesthet Dermatol 2013
24151358 New insights in bilirubin metabolism and their clinical implications

Jirsa, M, Sticová, E

World J. Gastroenterol. 2013
23297354 Human cytochromes P450 in health and disease

Nebert, DW, Miller, WL, Wikvall, K

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2013
14697877 Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B

Shih, JC

Neurotoxicology 2004
24734162 Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia

Azimi, F, Azad, M, Mortazavi, Y, Jafariyan, M, Khatami, S

Iran J Ped Hematol Oncol 2014
Name Identifier Synonyms
inherited metabolic disorder DOID:655 Metabolic hereditary disorder, Inborn Errors of Metabolism, inborn metabolism disorder
Cite Us!