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NCOA2(869-1464) binds KAT6A(1-1118)
Stable Identifier
R-HSA-5579023
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NCOA2:KAT6A fusion protein causes acute myeloid leukemias
ReviewStatus
5/5
Locations in the PathwayBrowser
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Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
NCOA2(869-1464) binds KAT6A(1-1118) (Homo sapiens)
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Chromosomal aberrations involving nuclear receptor coactivator 2 (NCOA2) and histone acetyltransferase KAT6A (KAT6A aka MOZ) may be a cause of acute myeloid leukemias. Inversion inv8(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation (Carapeti et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
9558366
A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia
Goldman, JM
,
Aguiar, RC
,
Carapeti, M
,
Cross, NC
Blood
1998
Participants
Input
KAT6A (1-1118) [nucleoplasm]
(Homo sapiens)
NCOA2 (869-1464) [nucleoplasm]
(Homo sapiens)
Output
NCOA2(869-1464):KAT6A(1-1118) [nucleoplasm]
(Homo sapiens)
Participates
as an event of
HATs acetylate histones (Homo sapiens)
Orthologous Events
NCOA2(869-1464) binds KAT6A(1-1118) (Bos taurus)
NCOA2(869-1464) binds KAT6A(1-1118) (Canis familiaris)
NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)
NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)
NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)
NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)
NCOA2(869-1464) binds KAT6A(1-1118) (Rattus norvegicus)
NCOA2(869-1464) binds KAT6A(1-1118) (Sus scrofa)
NCOA2(869-1464) binds KAT6A(1-1118) (Xenopus tropicalis)
Authored
Jassal, B (2014-06-06)
Reviewed
D'Eustachio, P (2015-02-11)
Created
Jassal, B (2014-06-06)
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