TNRC6A:AGO2:miRNA is transported into the nucleus

Stable Identifier
R-HSA-5578966
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TNRC6A:AGO2:miRNA is transported into the nucleus
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TNRC6A (GW182) possesses both a nuclear localization signal (NLS) and a nuclear export signal (NES) that enable it to shuttle between the cytoplasm and the nucleus (Nishi et al. 2013). Thus the TNRC6A:AGO2:miRNA complex is transported into the nucleus by an unknown importation mechanism (Nishi et al. 2013). (TNRC6A is exported by Exportin 1.) The interaction between AGO2 and TNRC6A affects gene silencing activity in the nucleus (Nishi et al. 2013).

Literature References
PubMed ID Title Journal Year
23150874 Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

Nishi, A, Nishi, K, Nagasawa, T, Ui-Tei, K

RNA 2013
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Orthologous Events
TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)
TNRC6A:AGO2:miRNA is transported into the nucleus (Danio rerio)
TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)
TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Mus musculus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)
TNRC6A:AGO2:miRNA is transported into the nucleus (Xenopus tropicalis)
Authored
May, B  (2014-05-31)
Reviewed
Li, LC  (2014-08-25)
Stroynowska-Czerwinska, A  (2014-09-06)
Created
May, B  (2014-06-06)
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