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TNRC6A:AGO2:miRNA is transported into the nucleus
Stable Identifier
R-HSA-5578966
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)
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TNRC6A (GW182) possesses both a nuclear localization signal (NLS) and a nuclear export signal (NES) that enable it to shuttle between the cytoplasm and the nucleus (Nishi et al. 2013). Thus the TNRC6A:AGO2:miRNA complex is transported into the nucleus by an unknown importation mechanism (Nishi et al. 2013). (TNRC6A is exported by Exportin 1.) The interaction between AGO2 and TNRC6A affects gene silencing activity in the nucleus (Nishi et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
23150874
Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus
Nishi, A
,
Nishi, K
,
Nagasawa, T
,
Ui-Tei, K
RNA
2013
Participants
Input
TNRC6A:AGO2:miRNA [cytosol]
(Homo sapiens)
Output
TNRC6A:AGO2:miRNA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transcriptional regulation by small RNAs (Homo sapiens)
Orthologous Events
TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)
TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)
TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Mus musculus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)
TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)
Authored
May, B (2014-05-31)
Reviewed
Li, LC (2014-08-25)
Stroynowska-Czerwinska, A (2014-09-06)
Created
May, B (2014-06-06)
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