BCDIN3D dimethylates 5' phosphate of pre-miR-145

Stable Identifier
R-HSA-5578717
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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BCDIN3D dimethylates 5' phosphate of pre-miR-145
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BCDIN3D transfers a methyl group from S-adenosylcysteine to the each of the 2 hydroxyl groups of the 5' phosphate of pre-miR-145 and pre-miR-23b (Xhemalce et al. 2012). The methylation eliminates the negative charges on the phosphate and thereby interferes with the recognition of pre-miRNAs by Dicer, inhibiting production of mature miR-145.
Literature References
PubMed ID Title Journal Year
23063121 Human RNA methyltransferase BCDIN3D regulates microRNA processing

Xhemalce, B, Kouzarides, T, Robson, SC

Cell 2012
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Catalyst Activity

O-methyltransferase activity of BCDIN3D [cytosol]

Physical Entity
BCDIN3D [cytosol] (Homo sapiens)
Activity
O-methyltransferase activity (GO:0008171)
Authored
May, B  (2014-05-30)
Reviewed
Kouzarides, T  (2017-10-23)
Created
May, B  (2014-05-31)
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