BCDIN3D dimethylates 5' phosphate of pre-miR-145

Stable Identifier
R-HSA-5578717
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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BCDIN3D transfers a methyl group from S-adenosylcysteine to the each of the 2 hydroxyl groups of the 5' phosphate of pre-miR-145 and pre-miR-23b (Xhemalce et al. 2012). The methylation eliminates the negative charges on the phosphate and thereby interferes with the recognition of pre-miRNAs by Dicer, inhibiting production of mature miR-145.

Literature References
PubMed ID Title Journal Year
23063121 Human RNA methyltransferase BCDIN3D regulates microRNA processing

Xhemalce, B, Robson, SC, Kouzarides, T

Cell 2012
Participants
Participates
Catalyst Activity

O-methyltransferase activity of BCDIN3D [cytosol]

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