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Phase 4 - resting membrane potential
Stable Identifier
R-HSA-5576886
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 4 - resting membrane potential (Homo sapiens)
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Phase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+ and relatively impermeable to other ions therefore the K+ gradient across the cell membrane is the key determinant in the normal resting potential (Park & Fishman 2011, Grant 2009). In this phase, K+ currents are generated by inward rectifier potassium channels (KCNJs) and tandem pore domain K+ channels (KCNKs). Some Na+/K+-ATPases and Na+/Ca2+-exchangers can also play roles during this phase.
Literature References
PubMed ID
Title
Journal
Year
21357845
The cardiac conduction system
Park, DS
,
Fishman, GI
Circulation
2011
19808464
Cardiac ion channels
Grant, AO
Circ Arrhythm Electrophysiol
2009
Participants
Events
KCNJs transport K+ from the extracellular region to cytosol
(Homo sapiens)
KCNK dimers transport K+ from cytosol to extracellular region
(Homo sapiens)
Participates
as an event of
Cardiac conduction (Homo sapiens)
Event Information
Go Biological Process
cardiac conduction (0061337)
Orthologous Events
Phase 4 - resting membrane potential (Bos taurus)
Phase 4 - resting membrane potential (Caenorhabditis elegans)
Phase 4 - resting membrane potential (Canis familiaris)
Phase 4 - resting membrane potential (Danio rerio)
Phase 4 - resting membrane potential (Drosophila melanogaster)
Phase 4 - resting membrane potential (Gallus gallus)
Phase 4 - resting membrane potential (Mus musculus)
Phase 4 - resting membrane potential (Rattus norvegicus)
Phase 4 - resting membrane potential (Saccharomyces cerevisiae)
Phase 4 - resting membrane potential (Sus scrofa)
Phase 4 - resting membrane potential (Xenopus tropicalis)
Authored
Jassal, B (2014-05-27)
Reviewed
Colotti, G (2015-11-09)
Created
Jassal, B (2014-05-27)
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