Phase 4 - resting membrane potential

Stable Identifier
R-HSA-5576886
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Pathway
Species
Homo sapiens
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5/5
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Phase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+ and relatively impermeable to other ions therefore the K+ gradient across the cell membrane is the key determinant in the normal resting potential (Park & Fishman 2011, Grant 2009). In this phase, K+ currents are generated by inward rectifier potassium channels (KCNJs) and tandem pore domain K+ channels (KCNKs). Some Na+/K+-ATPases and Na+/Ca2+-exchangers can also play roles during this phase.
Literature References
PubMed ID Title Journal Year
21357845 The cardiac conduction system

Park, DS, Fishman, GI

Circulation 2011
19808464 Cardiac ion channels

Grant, AO

Circ Arrhythm Electrophysiol 2009
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