Reactome | MED16 [nucleoplasm]

MED16 [nucleoplasm]

Stable Identifier

R-HSA-556802

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 16, MED16_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED16 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED16 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2X0 MED16

Gene Names

MED16, DRIP92, THRAP5

Chain

chain:1-877

Reference Genes

BioGPS Gene:10025 MED16

COSMIC (genes):MED16 MED16

CTD Gene:10025 MED16

dbSNP Gene:10025 MED16

ENSEMBL:ENSG00000175221 MED16

HGNC:17556 MED16

KEGG:hsa:10025 MED16

Monarch:10025 MED16

NCBI Gene:10025 MED16

OMIM:604062 MED16

UCSC:Q9Y2X0 MED16

Reference Transcript

RefSeq:NM_005481.2 MED16

Other Identifiers

10025

11744547_x_at

11745655_x_at

11753464_x_at

11753523_x_at

11753643_x_at

11753748_x_at

11755741_x_at

11756057_a_at

16866514

221418_PM_s_at

221418_s_at

221544_PM_s_at

221544_s_at

221545_PM_x_at

221545_x_at

221938_PM_x_at

221938_x_at

3844823

3844824

3844825

3844826

3844827

3844828

3844829

3844830

3844832

3844833

3844834

3844835

3844836

3844837

3844838

3844839

3844840

3844841

3844842

3844844

3844845

3844846

3844847

3844848

3844849

3844850

3844851

3844852

3844853

3844854

43544_PM_at

43544_at

45754_at

8032106

A_23_P56170

GE58368

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0016020

GO:0016592

GO:0032968

GO:0042809

GO:0043226

GO:0045893

GO:0046966

GO:0051123

GO:0060090

GO:0060261

GO:0065003

GO:0070847

GO:0140110

HMNXSV003017075

Hs.31659.0.S1_3p_a_at

ILMN_1719185

ILMN_1730307

ILMN_1790782

ILMN_1800451

TC19000991.hg

TC19002278.hg

TC19002279.hg

g4885646_3p_s_at

p26736

Participates

as a component of

as an input of

Inferred To

Med16 [nucleoplasm] (Rattus norvegicus)

med16 [nucleoplasm] (Danio rerio)

MED16 [nucleoplasm] (Bos taurus)

MED16 [nucleoplasm] (Canis familiaris)

MED16 [nucleoplasm] (Drosophila melanogaster)

MED16 [nucleoplasm] (Gallus gallus)

MED16 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005472.2

OpenTargets

ENSG00000175221

ENSEMBL

ENST00000395808, ENST00000312090, ENSP00000325612, ENST00000325464, ENSP00000308528, ENSP00000379153

HPA

ENSG00000175221-MED16

PRO

Q9Y2X0

Pharos - Targets

Q9Y2X0

GlyGen

Q9Y2X0

PDB

7LBM, 7ENC, 7ENA, 7EMF, 8GXQ, 7ENJ, 8GXS

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.825	7
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	8
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.788	6
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.744	6
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.695	5
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.669	4
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.643	3
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	5
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.643	5
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.643	4
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.643	5
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.564	3
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.564	4
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.527	3
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.527	4
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.527	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	3
UniProt:Q15528 MED22	1	MED22 [nucleoplasm] (R-HSA-556779)	0.527	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.527	3
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4

Cite Us!