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MED22 [nucleoplasm]
Stable Identifier
R-HSA-556779
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mediator of RNA polymerase II transcription subunit 22, MED22_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
NS1 (1C) binds to Mediator complex (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Mediator:NS1 [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15528 MED22
Gene Names
MED22, SURF5
Chain
chain:1-200
Reference Genes
BioGPS Gene:6837 MED22
COSMIC (genes):MED22 MED22
CTD Gene:6837 MED22
dbSNP Gene:6837 MED22
ENSEMBL:ENSG00000148297 MED22
HGNC:11477 MED22
KEGG:hsa:6837 MED22
Monarch:6837 MED22
NCBI Gene:6837 MED22
OMIM:185641 MED22
UCSC:Q15528 MED22
Reference Transcript
RefSeq:NM_133640.4 MED22
RefSeq:NM_181491.2 MED22
Participates
as a component of
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
Cross References
OpenTargets
ENSG00000148297
ENSEMBL
ENST00000343730
,
ENSP00000478773
,
ENSP00000342343
,
ENSG00000148297
,
ENSP00000485715
,
ENST00000626118
,
ENSP00000482438
,
ENST00000610672
,
ENST00000631196
,
ENST00000614493
,
ENSP00000481493
,
ENSP00000486722
,
ENST00000629975
,
ENST00000610888
,
ENSG00000281022
,
ENST00000629522
,
ENSP00000487580
,
ENSP00000485880
HPA
ENSG00000148297-MED22
GeneCards
MED22
PRO
Q15528
Pharos - Targets
Q15528
GlyGen
Q15528
PDB
8GXS
,
7LBM
,
7NVR
,
7ENJ
,
8GXQ
,
7ENC
,
7ENA
,
8TQW
,
8TRH
,
8T9D
,
7EMF
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.901
9
UniProt:Q9NVC6 MED17
1
MED17 [nucleoplasm]
(R-HSA-212401)
0.813
7
UniProt:Q6P2C8 MED27
1
MED27 [nucleoplasm]
(R-HSA-556761)
0.758
7
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.671
6
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.671
8
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.643
5
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.643
5
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.643
4
UniProt:Q96G25 MED8
1
MED8 [nucleoplasm]
(R-HSA-556784)
0.527
4
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
3
UniProt:O60244 MED14
1
MED14 [nucleoplasm]
(R-HSA-212441)
0.527
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.527
3
UniProt:Q9Y2X0 MED16
1
MED16 [nucleoplasm]
(R-HSA-556802)
0.527
3
UniProt:O75448 MED24
1
MED24 [nucleoplasm]
(R-HSA-212331)
0.527
3
UniProt:O75586 MED6
1
MED6 [nucleoplasm]
(R-HSA-212359)
0.527
3
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.527
3
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.483
3
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