Reactome | MED22 [nucleoplasm]

MED22 [nucleoplasm]

Stable Identifier

R-HSA-556779

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 22, MED22_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED22 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED22 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15528 MED22

Gene Names

MED22, SURF5

Chain

chain:1-200

Reference Genes

BioGPS Gene:6837 MED22

COSMIC (genes):MED22 MED22

CTD Gene:6837 MED22

dbSNP Gene:6837 MED22

ENSEMBL:ENSG00000148297 MED22

HGNC:11477 MED22

KEGG:hsa:6837 MED22

Monarch:6837 MED22

NCBI Gene:6837 MED22

OMIM:185641 MED22

UCSC:Q15528 MED22

Reference Transcript

Participates

as a component of

Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000148297

ENSEMBL

ENST00000343730, ENSP00000478773, ENSP00000342343, ENSG00000148297, ENSP00000485715, ENST00000626118, ENSP00000482438, ENST00000610672, ENST00000631196, ENST00000614493, ENSP00000481493, ENSP00000486722, ENST00000629975, ENST00000610888, ENSG00000281022, ENST00000629522, ENSP00000487580, ENSP00000485880

HPA

ENSG00000148297-MED22

GeneCards

MED22

PRO

Q15528

Pharos - Targets

Q15528

GlyGen

Q15528

PDB

8GXS, 7LBM, 7NVR, 7ENJ, 8GXQ, 7ENC, 7ENA, 8TQW, 8TRH, 8T9D, 7EMF

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.901	9
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.813	7
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.758	7
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	6
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.671	8
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.643	5
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.643	5
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.643	4
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.527	4
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.527	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.527	3
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.527	3
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.527	3
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.527	3
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.527	3
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.483	3