Defective Mismatch Repair Associated With MLH1

Stable Identifier
R-HSA-5545483
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The MLH1:PMS2 complex is homologous to the E. coli MutL gene and is involved in DNA mismatch repair. Heterozygous mutations in the MLH1 gene result in hereditary nonpolyposis colorectal cancer-2 (Papadopoulos et al., 1994).

Literature References
PubMed ID Title Journal Year
12419761 Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review

Mitchell, RJ, Farrington, SM, Dunlop, MG, Campbell, H

Am. J. Epidemiol. 2002
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
Cite Us!