Expression of PERIOD-1

Stable Identifier
R-HSA-549533
Type
Reaction [omitted]
Species
Homo sapiens
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The PERIOD-1 (PER1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The promoter of the PER1 gene contains E-boxes which are bound by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer). The BMAL1:CLOCK heterodimer activates transcription of PER1.

Literature References
PubMed ID Title Journal Year
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM

Neuron 1997
9333243 Circadian oscillation of a mammalian homologue of the Drosophila period gene

Tei, H, Okamura, H, Shigeyoshi, Y, Fukuhara, C, Ozawa, R, Hirose, M, Sakaki, Y

Nature 1997
14750904 Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

Miyazaki, K, Nagase, T, Mesaki, M, Narukawa, J, Ohara, O, Ishida, N

Biochem J 2004
17994337 Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways

Motzkus, D, Loumi, S, Cadenas, C, Vinson, C, Forssmann, WG, Maronde, E

Chronobiol Int 2007
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