Expression of PERIOD-1

Stable Identifier
R-HSA-549533
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The PERIOD-1 (PER1) gene is transcribed to yield mRNA and the mRNA is translated to yield PER1 protein (Shearman et al. 1997, Tei et al. 1997, Miyazaki et al. 2004, Motzkus et al. 2007, also inferred from mouse homologs). The promoter of the PER1 gene contains E-boxes which are bound by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer). The BMAL1:CLOCK heterodimer activates transcription of PER1.

Literature References
PubMed ID Title Journal Year
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM

Neuron 1997
9333243 Circadian oscillation of a mammalian homologue of the Drosophila period gene

Tei, H, Okamura, H, Shigeyoshi, Y, Fukuhara, C, Ozawa, R, Hirose, M, Sakaki, Y

Nature 1997
14750904 Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

Miyazaki, K, Nagase, T, Mesaki, M, Narukawa, J, Ohara, O, Ishida, N

Biochem J 2004
17994337 Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways

Motzkus, D, Loumi, S, Cadenas, C, Vinson, C, Forssmann, WG, Maronde, E

Chronobiol Int 2007
Participants
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This event is regulated
Negatively by
Regulator
Summation

As inferred from mouse homologs, the ICER isoform of CREM ( binds cAMP-responsive elements in the PER1 promoter and represses transcription of PER1 (Zmrzljak et al. 2013). Other isoforms of CREM may also repress PER1.

Positively by
Regulator
Summation

The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds E-boxes in the promoter of the PER1 gene and activates transcription of PER1. NPAS2 is predicted to act redundantly with CLOCK.

Regulator
Summation

As inferred from mouse homologs, RBM4 (hLARK) binds the 3' UTR of PER1 mRNA and increases production of PER1 protein probably by enhancing translation (Kojima et al. 2007).

Inferred From
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