Expression of PERIOD-2

Stable Identifier
R-HSA-549493
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The PERIOD-2 (PER2) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The promoter of the PER2 gene contains an E-box which binds the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer). The BMAL1:CLOCK heterodimer activates transcription of PER2.

Literature References
PubMed ID Title Journal Year
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM

Neuron 1997
18317514 Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems

Nakamura, K, Inoue, I, Takahashi, S, Komoda, T, Katayama, S

PPAR Res 2008
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