Expression of NR1D1 (REV-ERBA)

Stable Identifier
R-HSA-549475
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
NRID1 gene produces NRID1
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The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and the mRNA is translated to yield NR1D1 protein (Miyajima et al. 1989, Adelmant et al. 1996, also inferred from mouse homologs). In mouse the Rev-erba gene shows circadian expression due to transactivation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer. REV-ERBA binds the promoter of its own gene and represses its own expression (Adelmant et al. 1996).

Literature References
PubMed ID Title Journal Year
2539258 Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

Miyajima, N, Horiuchi, R, Shibuya, Y, Fukushige, S, Matsubara, K, Toyoshima, K, Yamamoto, T

Cell 1989
8622974 A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity

Adelmant, G, Bègue, A, Stéhelin, D, Laudet, V

Proc Natl Acad Sci U S A 1996
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This event is regulated
Negatively by
Regulator
Summation

NR1D1 (REV-ERBA) binds its own promoter and represses its own expression.

Positively by
Regulator
Summation

Activation of NR1D1 (REV-ERBA) expression by phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) is inferred from mouse. NPAS2 is predicted to act redundantly with CLOCK.

Regulator
Summation

As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). RORA binds the NR1D1 (REV-ERBA) promoter and activates transcription.

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