Expression of NR1D1 (REV-ERBA)

Stable Identifier
Reaction [uncertain]
Homo sapiens
NRID1 gene produces NRID1
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The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and the mRNA is translated to yield NR1D1 protein (Miyajima et al. 1989, Adelmant et al. 1996, also inferred from mouse homologs). In mouse the Rev-erba gene shows circadian expression due to transactivation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer. REV-ERBA binds the promoter of its own gene and represses its own expression (Adelmant et al. 1996).

Activation of NR1D1 (REV-ERBA) expression by phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) is inferred from mouse. NPAS2 is predicted to act redundantly with CLOCK.

As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). RORA binds the NR1D1 (REV-ERBA) promoter and activates transcription.

Literature References
PubMed ID Title Journal Year
8622974 A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity

Stéhelin, D, Adelmant, G, Laudet, V, Bègue, A

Proc Natl Acad Sci U S A 1996
2539258 Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

Yamamoto, T, Miyajima, N, Fukushige, S, Matsubara, K, Toyoshima, K, Horiuchi, R, Shibuya, Y

Cell 1989
This event is regulated