The CRYPTOCHROME-2 (CRY2) gene is transcribed to yield mRNA and the mRNA is translated to yield CRY2 protein (Kobayashi et al. 1998, Thompson et al. 2003, also inferred from mouse homologs). As inferred from mouse, the CRY2 protein shows circadian rhythm in the suprachiasmatic nucleus (SCN) and in peripheral tissues. The mRNA shows circadian rhythm in muscle but not in the SCN. Expression is dependent on CLOCK.
Kanno, S, Smit, B, Yasui, A, Kobayashi, K, Takao, M, van der Horst, GT
Ebright, JN, Kelly, U, Bowes Rickman, C, Rickman, DW, Sancar, A, Thompson, CL, Shaw, SJ
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