Expression of CRYPTOCHROME-1

Stable Identifier
R-HSA-549467
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of CRYPTOCHROME-1
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The CRYPTOCHROME-1 (CRY1) gene is transcribed to yield mRNA and the mRNA is translated to yield CRY1 protein (van der Spek et al. 1996, Thompson et al. 2003, also inferred from mouse homologs). CRY1 mRNA and protein show circadian expression. The promoter of the CRY1 gene contains an E-box which is bound by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 heterodimer), which activates transcription of CRY1. The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box in the promoter of the CRY1 gene and activates transcription of CRY1. NPAS2 is predicted to act redundantly with CLOCK.
Literature References
PubMed ID Title Journal Year
8921389 Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors

van der Spek, PJ, Bootsma, D, Yasui, A, Kobayashi, K, Eker, AP, Takao, M

Genomics 1996
14507900 Expression of the blue-light receptor cryptochrome in the human retina

Ebright, JN, Kelly, U, Bowes Rickman, C, Rickman, DW, Sancar, A, Thompson, CL, Shaw, SJ

Invest Ophthalmol Vis Sci 2003
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Output
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as an event of
This event is regulated
Positively by
Regulator
p-BMAL1:p-CLOCK,NPAS2:CRY1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Cryptochrome-1 (Cry1) (Mus musculus)
Authored
May, B  (2010-03-11)
Reviewed
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-21)
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