Expression of FACTOR VII (F7)

Stable Identifier
R-HSA-549428
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum lumen
ReviewStatus
5/5
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Expression of FACTOR VII (F7)
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The FACTOR VII (F7) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. In mouse the promoter of the F7 gene contains an E-box which binds the Bmal1:Clock (Arntl:Clock) heterodimer and the Bmal1:Npas2 (Arntl:Npas2) heterodimer, conferring circadian expression on Factor VII mRNA and protein. Activation of FACTOR VII expression by phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) is inferred from mouse. NPAS2 is predicted to act redundantly with CLOCK.
Literature References
PubMed ID Title Journal Year
8618898 Liver-specific expression of the human factor VII gene

Chung, DW, Greenberg, D, Miao, CH, Ho, WT, Davie, EW

Proc Natl Acad Sci U S A 1995
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Output
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This event is regulated
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Regulator
p-BMAL1:p-CLOCK,NPAS2:F7 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Coagulation Factor VII (F7) (Mus musculus)
Authored
May, B  (2010-03-19)
Reviewed
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-21)
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