Expression of SERPINE1 (PAI-1)

Stable Identifier
R-HSA-549364
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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Expression of SERPINE1 (PAI-1)
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The phosphorylated BMAL1:CLOCK (ARNTL) heterodimer binds an E-box in the promoter of the PAI-1 gene and activate transcription of PAI-1. NPAS2 is predicted to act redundantly with CLOCK. The PAI-1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The PAI-1 gene shows circadian expression due to direct transcriptional activation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer and the BMAL2:CLOCK (CLIF:CLOCK, ARNTL2:CLOCK) heterodimer. BMAL2 (ARNTL2, CLIF) forms a heterodimer with CLOCK, binds E-boxes in the PAI-1 promoter and activates transcription of the PAI-1 gene. BMAL2 shows constitutive rather than circadian expression.
Literature References
PubMed ID Title Journal Year
11018023 CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression

de la Monte, SM, Yet, SF, Layne, MD, Chin, MT, Maemura, K, Lee, ME, Hsieh, CM, Perrella, MA

J Biol Chem 2000
16857194 Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference

Samani, NJ, Chong, NW, Codd, V, Chan, D

FEBS Lett 2006
12406875 The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1

van der Bom, JG, Bots, ML, Kluft, C, Haverkate, F, Grobbee, DE

Blood 2003
12738229 Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

Eren, M, Smith, LH, Vaughan, DE, Johnson, CH, Painter, CA, Schoenhard, JA

J Mol Cell Cardiol 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
BMAL2:CLOCK [nucleoplasm] (Homo sapiens)
Regulator
p-BMAL1:p-CLOCK,NPAS2:SERPINE1 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-03-19)
Reviewed
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-21)
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