Expression of SERPINE1 (PAI-1)

Stable Identifier
Reaction [omitted]
Homo sapiens
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The PAI-1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The PAI-1 gene shows circadian expression due to direct transcriptional activation by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer and the BMAL2:CLOCK (CLIF:CLOCK, ARNTL2:CLOCK) heterodimer.

Literature References
PubMed ID Title Journal Year
16857194 Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference

Chong, NW, Codd, V, Chan, D, Samani, NJ

FEBS Lett 2006
11018023 CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression

Maemura, K, de la Monte, SM, Chin, MT, Layne, MD, Hsieh, CM, Yet, SF, Perrella, MA, Lee, ME

J Biol Chem 2000
12406875 The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1

van der Bom, JG, Bots, ML, Haverkate, F, Kluft, C, Grobbee, DE

Blood 2003
12738229 Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

Schoenhard, JA, Smith, LH, Painter, CA, Eren, M, Johnson, CH, Vaughan, DE

J Mol Cell Cardiol 2003
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